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Sr. Medical Director
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Sr. Medical Director
Lexington, MA
Job Type
Full-time
Description
About TRIANA Biomedicines
TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries. TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients. TRIANA is a private company with a top-tier investor syndicate.
Position Overview:
We are seeking a Senior/Executive Medical Director to lead early-phase oncology clinical development. This role serves as the primary medical lead for one or more investigational compounds from first-in-human through proof of concept, driving clinical strategy, ensuring patient safety, and advancing programs toward key milestones.
You will work cross-functionally with translational science, biomarkers, regulatory, and portfolio teams to define and execute development plans. The ideal candidate is a physician-scientist with deep oncology expertise, hands-on early-phase trial experience (including CRO oversight), and a strong commitment to delivering innovative therapies to patients. Regulatory and global experience are a plus.
Key Responsibilities:
Clinical Strategy
Serve as the Medical Lead for early-phase oncology programs (FIH through proof of concept).
Develop Clinical Development Plans, including indication strategy, study design, and decision criteria.
Define dose-escalation approaches, expansion cohorts, and patient selection in partnership with translational and biomarker teams.
Drive data-informed decisions through safety reviews, data analyses, and portfolio discussions.
Study Design & Execution
Author and oversee key clinical documents (protocols, IBs, ICFs, CSRs).
Provide medical oversight for trial execution, including safety monitoring and investigator engagement.
Lead medical monitoring activities (AE review, signal detection, dose management).
Participate in or chair SRCs, DMCs/IDMCs, and internal governance meetings.
Partner with biostatistics on endpoints and analysis plans aligned with regulatory expectations.
Regulatory & Scientific Engagement
Contribute to regulatory submissions (INDs, amendments, briefing documents, responses).
Support regulatory interactions as a medical expert (FDA, EMA, global agencies).
Build relationships with KOLs, academic institutions, and patient advocacy groups.
Lead publications and present data internally, at conferences, and to external stakeholders.
Cross-Functional Leadership
Serve as a core Program Team member, providing medical leadership across functions.
Mentor junior clinical staff and contribute to team development.
Support business development activities, including scientific due diligence and partnerships.
Qualifications:
Required
MD, MD/PhD, or DO with board certification/eligibility in Oncology, Hematology/Oncology, or related field.
10+ years of industry experience, including 5+ years in biotech drug development.
Proven leadership in Phase I/II oncology trials, including FIH studies.
Strong expertise in oncology biology, biomarkers, and precision medicine.
Experience with regulatory submissions and health authority interactions.
Excellent communication skills with the ability to translate complex data clearly.
Preferred
Experience with accelerated regulatory pathways (e.g., Breakthrough Therapy, Fast Track, RMAT).
Global/ex-US clinical development experience.
We welcome applications from skilled individuals whose qualifications may not fit the criteria outlined above.
Base Salary: $300-$325k
Our Culture
Our Team is our greatest asset at TRIANA. We are proud to work with an integrated group of individuals from an extensive range of backgrounds and experiences. Diversity, Equity, Inclusion and Belonging are important aspects of our culture. We embrace our differences and cultivate an environment that drives better collaboration and innovation by striving to ensure that all coworkers have an ongoing positive experience while being their authentic selves.
Our Values
At TRIANA we are empowered to act. We dare to create transformative medicines for patients. Our creativity and dedication are the glue that unites us in pursuit of our mission.
Thank you for your interest in TRIANA!
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Listed by Triana Biomedicines for a position based in the United States. Employers on this board attest they are hiring domestically.
We are rebuilding biotech for the AI era.
When a breakthrough is delayed, the world waits. Getting a molecule from discovery to patients, or a crop from lab to field, involves thousands of slow, manual, disconnected steps. AI has the potential to change this, compressing decades of R&D work into years. But that only happens when clean, structured scientific data and AI are built into how science gets done.
Benchling is the AI platform for biotech R&D. Scientists use Benchling to design experiments, capture structured data, and run AI agents and models directly in their workflows. Over 200,000 scientists around the world trust Benchling to power their most important work, from academic labs to Sanofi, Moderna, and more than half of the world's top 50 biopharma.
We’re building an AI scientist for our customers. We can’t do that if we haven’t built the muscle ourselves. AI fluency is the foundation we build on; it's core to how we work, and we're committed to helping every new hire integrate it into their day-to-day. As part of our interview process, you'll complete a brief AI-focused exercise or discussion so we can understand how you think about and use AI to drive impact in your role. Feel free to reference any tools, platforms, or workflows you use today.
ROLE OVERVIEW
We're looking for a product manager who thinks like a developer advocate and acts like a platform strategist. This role sits at the intersection of systems integration and developer experience and as AI transforms how scientists work, the stakes have never been higher. The world's most innovative life sciences teams are already building agentic R&D workflows on top of Benchling, and they need a platform that can keep up. Your job is to understand what they're building, identify the gaps before they become blockers, and make the case internally for what needs to get built next.
You'll own the developer platform roadmap, serve as the internal voice of the external developer, and ensure that customer and partner learnings shape priorities across the Build org. This is a role for someone who is always six months ahead, anticipating what cutting-edge life sciences teams will need to build next, and making sure Benchling is ready when they get there.
RESPONSIBILITIES
- Own the end-to-end roadmap for Benchling's developer-facing products: REST APIs, MCPs, SDKs, API playground, code examples, and code recipes.
- Our most sophisticated customers are building agentic R&D workflows on top of Benchling and need primitives that don't exist yet. You'll define what those primitives are, get them built, and make sure developers can actually use them.
- Our partner ecosystem (Quilt, Calira, Code Ocean, Seqera, and others) needs extensibility that scales beyond one-off integrations. You'll work cross-functionally with Solutions Engineering, Partnerships, and Customer Success to build the platform foundation that makes this possible.
- Developers who try to build on Benchling today hit walls fast — in our docs, our APIs, and our support. You'll own the developer experience end-to-end and close the gap between what developers expect and what we deliver.
- We don't have a clear line of sight into how developers are actually using our platform. You'll establish the feedback loops through interviews, support signals, and usage data and make sure those learnings shape roadmap decisions across the Build org.
QUALIFICATIONS
REQUIRED:
- 3-5 years of product management experience, with hands-on ownership of API, SDK, or developer platform products
- Technical fluency: you can read code, review API specs, and have credible conversations with engineers. You don't need to ship production code, but you need to deeply understand the systems you're building
- Developer empathy at your core: you obsess over the developer experience and are constantly thinking about how AI-era tooling (MCPs, LLM-friendly APIs, agentic workflows) can supercharge what developers can do with Benchling
- Familiarity with the modern developer stack — APIs, SDKs, documentation, and developer onboarding; you understand the tradeoffs and know what good looks like
- Strong communicator: you write crisp requirements and can present clearly to engineers, stakeholders, and customers alike
Nice to Have:
- Familiarity with the life sciences or enterprise SaaS domain
- Experience building developer communities, running beta programs, or managing developer relations programs
- Prior experience at a company with a platform business model or marketplace
HOW WE WORK
We offer a flexible hybrid work arrangement that prioritizes in-office collaboration. Employees are expected to be on-site 3 days per week (Monday, Tuesday, and Thursday).
#LI-Hybrid
#BI-Hybrid
#EN-1
Benchling welcomes everyone.
We believe diversity enriches our team so we hire people with a wide range of identities, backgrounds, and experiences.
We are an equal opportunity employer. That means we don’t discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. We also consider for employment qualified applicants with arrest and conviction records, consistent with applicable federal, state and local law, including but not limited to the San Francisco Fair Chance Ordinance.
Listed by Benchling for a position based in the United States. Employers on this board attest they are hiring domestically.
Join Enveda as a Senior Research Associate, In Vivo Pharmacology in Hyderabad, India and help us transform natural compounds into life-changing medicines. We’re a team driven by curiosity and innovation—are you ready to make a difference?
Hyderabad, India | Full-time
What Makes Us Enveda
Life is smart, and we can learn from it. We’re reinventing drug discovery by harnessing nature’s intelligence. Our platform identifies new medicines four times faster than the industry standard because patients can’t wait.
What sets Enveda apart isn’t just what we do—it’s how we do it. Our culture is built on creativity, collaboration, and deep respect for each other. We believe “People Create All Value”, and our success is driven by the extraordinary team turning our mission into reality every day.
We’re proud of the momentum we’ve built.
Our Momentum
Unicorn status: Achieved following a $150 million Series D funding round in 2025
Discovery and innovation: Advanced our first drug candidate to Phase 1 trials in 2024
Award-winning culture:
Newsweek: Top 100 Global #MostLovedWorkplaces (2025)
Forbes: America’s Best Startup Employers (2024 & 2025)
These milestones reflect the impact of our team—and we’re just getting started. They’re only possible because of the diverse talent, perspectives, and relentless drive of our people, including individuals like you.
Your Role in Our Mission
At Enveda, every role drives impact. As a Senior Research Associate, In Vivo Pharmacology, you’ll be at the forefront of delivering hope to patients everywhere. Your expertise in in vivo pharmacology, disease model development, and translational research will be critical in accelerating our mission to discover and develop innovative therapeutics across multiple disease areas.
Listed by Enveda Biosciences for a position based in the United States. Employers on this board attest they are hiring domestically.
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Biotech/Pharma
127 days ago
Materials Engineer
Neuralink · South San Francisco, California, United States
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Materials Engineer
South San Francisco, California, United States
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About Neuralink:
We are creating devices that enable a bi-directional interface with the brain. These devices allow us to restore movement to the paralyzed, restore sight to the blind, and revolutionize how humans interact with their digital world.
Team Description:
The Materials Engineering Team at Neuralink develops and qualifies high-performance, biocompatible materials for next-generation brain-computer interfaces. The team owns material characterization, hermetic packaging reliability, accelerated lifetime testing, and predictive simulation for implantable neural devices. We operate at the intersection of physical testing and computational modeling, closing the loop between experiment and simulation to drive design decisions.
Job Description and Responsibilities:
We are looking for a Mechanical Engineer who owns the full simulation-to-test loop for implant mechanical reliability. This person will build explicit dynamics FEA models, design and run physical tests, calibrate material models against experimental data, and validate predictions. You will work closely with materials engineers, microfabrication, and cross-functional reliability teams to ensure the implant meets impact, fatigue, and seal integrity requirements.
Build, refine, and validate explicit dynamics Finite Element Analysis (FEA) models (LS-DYNA, Abaqus/Explicit) to predict mechanical response under high-strain-rate impact loading.
Own the in-house mechanical testing pipeline end-to-end: design fixtures, prepare specimens, run tests (servo-hydraulic, drop tower, DIC), and correlate results to simulation using quantitative metrics (CORA, force-displacement overlay, DIC contour comparison).
Translate physical test data into constitutive model inputs: calibrate material cards, optimize parameters, and deliver validated simulation files.
Coordinate test projects (SHPB, DMA, abuse testing) and own data quality from external sources.
Extend validated impact models to adjacent reliability domains: burst/cyclic pressure testing, vibration fatigue, and seal interface simulation.
Support cross-functional reliability programs including thermal modeling, RH/leak modeling, and accelerated lifetime testing as needed
Required Qualifications:
MS or PhD in Mechanical Engineering, Materials Science, or related field.
2+ years of hands-on experience with explicit dynamics FEA (LS-DYNA, Abaqus/Explicit, or similar) - not static/modal only.
2+ years of hands-on experience with mechanical testing (tensile testers, DMA, servo-hydraulic frames, or similar equipment).
Experience with polymer or composite material characterization, including rate-dependent and temperature-dependent behavior.
Hands-on experience with mechanical assembly, fabrication, or building and calibrating test equipment.
Proficiency in mechanical design (SolidWorks or similar CAD software).
Familiarity with relevant test standards (ASTM, IEC).
Ability to work autonomously: define test plans, build fixtures, run tests, analyze data, and present conclusions
Preferred Qualifications:
Direct experience with high-strain-rate testing (SHPB, drop tower).
Experience with Digital Image Correlation (DIC) or full-field strain measurement.
Experience with constitutive model calibration and parameter optimization (fitting test data to LS-DYNA material cards such as MAT_SAMP-1, MAT_024, or cohesive zone models).
Medical device or aerospace reliability background (DV/V&V, FDA regulatory context).
Python for data processing and automation.
Experience correlating simulation to physical test data using quantitative metrics (CORA, force-displacement overlay, DIC contour comparison).
Experience calibrating and troubleshooting lab instrumentation.
Expected Compensation:
The anticipated base salary for this position is expected to be within the following range. Your actual base pay will be determined by your job-related skills, experience, and relevant education or training. We also believe in aligning our employees’ success with the company's long-term growth. As such, in addition to base salary, Neuralink offers equity compensation (in the form of Restricted Stock Units (RSU)) for all full-time employees.
Base Salary Range:
$113,000 - $209,000 USD
What We Offer:
Full-time employees are eligible for the following benefits listed below.
An opportunity to change the world and work with some of the smartest and most talented experts from different fields
Growth potential; we rapidly advance team members who have an outsized impact
Excellent medical, dental, and vision insurance through a PPO plan
Paid holidays
Commuter benefits
Meals provided
Equity (RSUs) *Temporary Employees & Interns excluded
401(k) plan *Interns initially excluded until they work 1,000 hours
Parental leave *Temporary Employees & Interns excluded
Flexible time off *Temporary Employees & Interns excluded
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Biotech/Pharma
129 days ago
AI Scientist - Biomedical Multimodal Modeling
Xaira Therapeutics · South San Francisco, California, United States
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AI Scientist - Biomedical Multimodal Modeling
South San Francisco, California, United States
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About Xaira Therapeutics
Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.
About the Role
We are building foundation models for biological systems, focusing on learning from complex, multimodal data. Our approach combines representation learning and generative modeling to capture structure, variation, and latent organization in high-dimensional settings. We work with both image-based data and high-dimensional molecular (omics) measurements, treating them as complementary views of the same underlying system. Our goal is to develop models that can both encode rich representations and generate or infer missing aspects from partial observations.
What You’ll Do
Develop multimodal foundation models spanning image and molecular data
Design approaches that unify representation learning and generative modeling
Train large-scale models on structured, high-dimensional datasets
Explore cross-modal alignment, prediction, and generation
Build scalable systems for data processing, training, and evaluation
Work in a research-driven environment with evolving problem definitions
What We’re Looking For
Strong background in deep learning, especially in modern architecture
Experience with representation learning (self-supervised, contrastive, masked modeling, etc.)
Experience with generative modeling (diffusion, autoregressive models, VAEs, or related approaches)
Proficiency in Python, ML frameworks, and CI/CD (PyTorch, JAX, etc.)
Relevant Experience
Work on multimodal learning or cross-domain representation learning
Experience with image data, molecular / omics-like data, or both
Familiarity with large-scale training
Bonus
Exposure to biological or scientific datasets
Experience with paired or partially aligned multimodal data
Comfortable working in open-ended, evolving problem spaces
Compensation
We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $170,000 - $240,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.
Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.
TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.
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As set forth in Xaira Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
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