Job Title: Manufacturing Operator – GMP Food Production

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today.

Why work at Manus:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Position Summary:
The Manufacturing Operator is responsible for safely operating and monitoring processing and packaging equipment within a GMP-regulated food manufacturing environment. This role requires maintaining product quality, ensuring accurate documentation, following established operating procedures, and supporting efficient production while maintaining high standards of safety, housekeeping, and attention to detail.

Essential Duties and Responsibilities:

• Operate and monitor a Bepex Flash Dryer while maintaining process temperatures between 112–120°C and ensuring process parameters remain within specifications.
• Operate and monitor baghouses to maintain proper airflow, dust collection, and efficient system performance.
• Maintain appropriate wet cake feed hopper levels to support continuous and efficient production flow.
• Safely operate and monitor screw conveyors, pasteurizers, and paddle conveying cooling systems.
• Package finished product into 10 kg boxes while maintaining a high level of accuracy and consistency.
• Construct, assemble, and properly fill 10 kg product boxes according to established packaging procedures.
• Maintain a high level of attention to detail during packaging operations to ensure product quality and packaging accuracy.
• Complete and review batch records with a high degree of accuracy and ensure documentation is complete, legible, and compliant with GMP requirements.
• Identify and communicate process deviations, equipment issues, or quality concerns to supervision promptly.
• Adhere to all Good Manufacturing Practices (GMPs), food safety policies, SOPs, and safety requirements.
• Maintain a high standard of daily housekeeping, including cleaning equipment, workstations, and surrounding production areas.
• Support continuous improvement efforts and contribute to efficient production operations.
• Work effectively as part of a team to meet production goals and schedules.

Required Skills and Qualifications:

• High school diploma or equivalent preferred.
• Manufacturing or food production experience preferred.
• Knowledge of GMP requirements, food safety standards, and documentation practices preferred.
• Ability to accurately complete and review production records and batch documentation.
• Strong attention to detail and ability to maintain accuracy in a fast-paced production environment.
• Ability to safely operate manufacturing equipment and follow established procedures.
• Strong communication and teamwork skills.
• Ability to lift and move materials/products as required.
• Ability to stand, walk, bend, and perform repetitive physical tasks for extended periods.

Physical Requirements:

• Ability to lift up to 50 pounds as required.
• Ability to work in manufacturing environments with varying temperatures, equipment noise, and moving machinery.
• Ability to wear required PPE and comply with all safety standards.

Manus Bio is a next-generation industrial biotechnology company head quarted in Cambridge, Massachusetts that produces plant-based ingredients. We use a variety of patented and proprietary technologies to engineer microbes for the production of specialty chemicals, such as food ingredients, agricultural chemicals, and pharmaceuticals. We are seeking a highly motivated Fermentation Plant Operator. This person will be expected to play an integral part of Manus Bio’s manufacturing and process development team located in Augusta, GA.

The Chemical/Fermentation Plant Operator is responsible for the continuing efficient operation of the fermentation plant and providing overtime support as needed for production. This includes maintenance, equipment reliability, and operations. Creativity and decision-making skills are required. Must be able to maintain a good working relationship with all personnel. Work as a member of the fermentation plant team which includes assisting in the Pilot Plant. Controls, monitors, and measures fermentation processes as instructed. Abides by all safely, environmental, and quality requirements. Perform minor maintenance and duties related to product testing, including sampling.

Why work at Manus Bio:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that come with working on the cutting edge.

Responsibilities:

Interface with production to provide resources to solve fermentation and product isolation problems.

Execute and help evaluate fermentation experiments. This activity includes:

• Prepare fermentation and downstream equipment in accordance to SOPs, this include equipment setup, media make up, equipment disassembly, cleaning, etc.
• Collect samples during manufacturing process for analytical analysis.
• Prepare all required batch records, reflect constantly changing experimental designs and ensure clear communication to the process development subject matter expert of the targeted design parameters.
• Collect and review all batch records. Data reduction includes electronic data conversion into and formatting in Excel for purposes of trending key operational parameters. Data is reviewed and checked. Off-line analytical data is reviewed for accuracy, retesting if necessary. Final results are organized and distributed to the process development subject matter expert.
• Coordinate day-to-day Fermentation Plant activities, including manufacturing scheduling conflicts, coordinating equipment maintenance and installation activities, troubleshooting process upsets, troubleshooting equipment and instrumentation problems, optimizing operations, addressing contamination issues, addressing downtime or other runtime losses.
• Prepare SOP for new process or operations as needed.
• Assist and provide hands-on support of Fermentation Plant maintenance activities, including rebuilding of probes and housings, changing out gear boxes on vessels, rebuilding valves, piping modifications, and modifying/fabricating new and existing equipment.
• Maintain the upkeep of the Fermentation Plant equipment through the process of initiating work notifications/work orders and maintenance scheduling; Use your own tools to correct minor maintenance issues is encouraged.
• Adhere to company EH&S policies and procedure. Ensure fermentation plant compliance with safety and environmental regulations.
• Physical demand requirements are in excess of sedentary work due to inspection of equipment. Must be able to climb stairs and ladders.
• Must be able to wear required protective equipment including respirators (if needed).
• Work schedule is considered shift but will vary depending on manufacturing plan and and other extraordinary conditions.
• Ensure Fermentation plant compliance with safety and environmental regulations.

Required Qualifications:

• High school diploma or GED equivalent.
• Minimum of 3 years fermentation or related plant operator experience.
• Must be able to follow minimal instructions and support safe work practices.

• Must be an excellent team member with strong communication skills and a desire to work collaboratively.
• Must be flexible with day-to-day duties and able to thrive in a start-up environment.
• Must hold themselves to the highest professional and ethical standards.
• Familiar with the production fermentation and downstream processes and equipment as well as microbiological and analytical laboratory procedures.
• Demonstrates flexibility in job rotations/various assignments.
• Basic PC skills which include Windows, Microsoft Office.

Preferred Qualification and Working Style:

• SAP skills
• Certified Train the Trainer skills
• Delta V controls experience

Job Type: Regular, Full-Time

Employee Status: Permanent

Research Scientist, Strain and Enzyme Engineering Waltham, MA United States, Full-Time

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today.

We are seeking a motivated Strain and Enzyme Scientist to help advance the development of natural BioAlternatives in Escherichia coli. In this role, you will apply creative, collaborative approaches to engineer microbial strains and enzymes, identify and overcome metabolic bottlenecks, and optimize pathways for improved biomanufacturing performance. You will use your expertise in molecular biology, strain engineering, and protein engineering to design, build, and evaluate strains and enzyme variants through high-throughput, plate-based screening. You will also partner closely with our skilled process development team to scale promising strains in bioreactors. This is an opportunity to contribute across the full development cycle, from early-stage design and optimization through scale-up.

This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative. This person will be expected to play an integral part of Manus’s research and development team located in Waltham, MA.

Why work for the Company:

Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.

Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.

Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Responsibilities:

• Strain Engineering: Identify and address metabolic bottlenecks, and design, construct, and optimize biosynthetic pathways using metabolic engineering and synthetic biology tools.
• Enzyme Engineering: Apply design-build-test-learn (DBTL) approaches to evaluate enzyme panels and engineered variants, improve pathway activity, and overcome key performance limitations.
• Molecular Biology: Design, construct, and validate vectors for gene expression, enzyme evaluation, and pathway engineering in microbial hosts.
• Strain Construction: Generate E. coli strains using techniques such as recombineering and CRISPR-based genome editing to support strain development campaigns.
• High-Throughput Experimentation: Develop and execute efficient screening workflows to evaluate strain and enzyme performance and identify promising candidates.
• Analytical Execution: Operate GC and/or LC instrumentation to quantitatively assess strain performance, including titer, yield, productivity, and product profile.
• Scientific Innovation: Develop and test data-driven hypotheses, translate experimental insights into actionable strategies, and deliver creative solutions to complex technical challenges.
• Cross-Functional Collaboration: Communicate findings and work closely with colleagues across strain engineering, fermentation, analytical sciences, and downstream processing to accelerate development and improve experimental outcomes.
• Data Management: Maintain accurate and complete experimental records, process results, and ensure timely data entry into LIMS and other designated systems.

Required Qualifications:

• Ph.D. or equivalent in Bioengineering, Chemical Engineering, Biochemistry, Microbiology, or a related field
• Hands-on experience in genetic engineering tools, including cloning, pathway assembly, and chromosomal manipulation
• Knowledge of enzyme engineering and DBTL workflows
• Expertise in microbial physiology and metabolism

Preferred Qualifications:

• Experience engineering E. coli or other similar microorganisms
• Analytical chemistry experience, including GC, LC, and LC/MS

Preferred Working Style:

• Must be very well-organized and be able to handle multiple projects simultaneously.
• Must be a quick learner who is self-motivated and able to ask questions and seek clarity.
• Must be flexible with day-to-day duties and able to thrive in a dynamic environment.
• Must be an excellent team member with strong communication skills and a desire to work collaboratively.
• Must hold themselves to the highest professional, scientific and ethical standards.

Process Design Engineer Augusta, Georgia, United States, Full-Time

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today. We are seeking a self-motivated and highly organized individual for a position that will specialize in and lead all laboratory operations at our Boston BioFacility.

We are seeking a highly motivated Process Design Engineer to assist with design of new processes, optimization of existing processes, capital projects, recommissioning, and startup. The ideal candidate will have expertise process design (conceptual development, line sizing, equipment sizing, mass & energy balances), process engineering (optimization, instrumentation, and data collection), engineering documentation (EFDs, PFDs, P&IDs, isometric drawings, dimensional drawings, document control, etc.), and process safety. This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative applied to the various duties and aspects of the position. This person will be expected to play an integral part of Manus Bio’s team located in Augusta, GA

Why work at Manus:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Key Responsibilities:?

• Initiates/supports conceptual design of new processes, including P&ID development, scale-up calculations, mass & energy balances, EFDs, and PFDs.
• Gather and organize information to be used for developing design.
• Initiates/supports capital projects, including scope development, cost justification, control logic and start-up support. Commissioning and water-batching is critical.
• Provides Process Safety Management ownership responsibilities including process hazard analysis participation, maintaining drawings, procedures, and PSI files, and sponsoring management of change for equipment and process changes.
• Troubleshooting design issues.
• Preparation of detailed engineering reports.
• Preparation of “as-built” drawing markups based on input or physical walk downs of systems.
• Work with Process Development teams to ensure appropriate lab experiments are performed and data is collected, that processes are appropriately scaled up to the pilot plant, and that necessary pilot data is collected.
• Assist with full scale-up of pilot processes.
• Assist with identifying plant material balances, capacity evaluations, area/plant yields, and KPIs that should be monitored and reported.
• When necessary, assist with specification and procurement of appropriate equipment, instrumentation, and materials.
• Inspect and report on new processes, upgrades, or retrofits for conformance to design.
• Conduct activities in a safe and healthy manner and work in accordance with established safety and company requirements.
• Promote a positive working environment in order to achieve the organization’s goals.
• Perform other duties as assigned.

Qualifications

• Minimum B.S. in Chemical Engineering required (other relevant engineering degree may be considered), and three (3) to fifteen (15) years of experience in plant engineering and/or process design.
• Strong understanding of engineering core fundamentals (i.e. thermodynamics, transport, kinetics).
• Experience in an industrial setting (not commercial).
• Must be able to read and understand P&ID’s at a high level.
• Excellent communication skills; both oral and written is required.
• Strong analytical and problem solving skills are required.
• Computer skills and an in-depth knowledge of Microsoft Windows based programs are required.
• Ability to work flexible hours.
• Requires effective time management skills, personal conduct, and change management abilities.
• Ability to effectively interact with co-workers, vendors, contractors and other business contacts.
• Must comply with Manus Bio’s core values for the safe and efficient operation of the business and maintain sound relationships among and with employees.

Preferred Qualifications?

• Training and experience in process hazard evaluation techniques as applied to OSHA 29 CFR 1910 requirements.
• Experience working in cGMP environments.
• Experience in biochemical, petrochemical, pharmaceutical, energy, oil and gas industries is preferred.
• Experience with engineering simulation tools (e.g. Aspen Plus, ChemCAD, etc.).

Augusta, Georgia, United States, Full-Time

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today. We are seeking a self-motivated and highly organized individual for a position that will specialize in and lead all laboratory operations at our Boston BioFacility.

We are seeking a highly motivated Process Design Engineer to assist with design of new processes, optimization of existing processes, capital projects, recommissioning, and startup. The ideal candidate will have expertise process design (conceptual development, line sizing, equipment sizing, mass & energy balances), process engineering (optimization, instrumentation, and data collection), engineering documentation (EFDs, PFDs, P&IDs, isometric drawings, dimensional drawings, document control, etc.), and process safety. This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative applied to the various duties and aspects of the position. This person will be expected to play an integral part of Manus Bio’s team located in Augusta, GA

Why work at Manus:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Key Responsibilities:?

• Initiates/supports conceptual design of new processes, including P&ID development, scale-up calculations, mass & energy balances, EFDs, and PFDs.
• Gather and organize information to be used for developing design.
• Initiates/supports capital projects, including scope development, cost justification, control logic and start-up support. Commissioning and water-batching is critical.
• Provides Process Safety Management ownership responsibilities including process hazard analysis participation, maintaining drawings, procedures, and PSI files, and sponsoring management of change for equipment and process changes.
• Troubleshooting design issues.
• Preparation of detailed engineering reports.
• Preparation of “as-built” drawing markups based on input or physical walk downs of systems.
• Work with Process Development teams to ensure appropriate lab experiments are performed and data is collected, that processes are appropriately scaled up to the pilot plant, and that necessary pilot data is collected.
• Assist with full scale-up of pilot processes.
• Assist with identifying plant material balances, capacity evaluations, area/plant yields, and KPIs that should be monitored and reported.
• When necessary, assist with specification and procurement of appropriate equipment, instrumentation, and materials.
• Inspect and report on new processes, upgrades, or retrofits for conformance to design.
• Conduct activities in a safe and healthy manner and work in accordance with established safety and company requirements.
• Promote a positive working environment in order to achieve the organization’s goals.
• Perform other duties as assigned.

Qualifications

• Minimum B.S. in Chemical Engineering required (other relevant engineering degree may be considered), and three (3) to fifteen (15) years of experience in plant engineering and/or process design.
• Strong understanding of engineering core fundamentals (i.e. thermodynamics, transport, kinetics).
• Experience in an industrial setting (not commercial).
• Must be able to read and understand P&ID’s at a high level.
• Excellent communication skills; both oral and written is required.
• Strong analytical and problem solving skills are required.
• Computer skills and an in-depth knowledge of Microsoft Windows based programs are required.
• Ability to work flexible hours.
• Requires effective time management skills, personal conduct, and change management abilities.
• Ability to effectively interact with co-workers, vendors, contractors and other business contacts.
• Must comply with Manus Bio’s core values for the safe and efficient operation of the business and maintain sound relationships among and with employees.

Preferred Qualifications?

• Training and experience in process hazard evaluation techniques as applied to OSHA 29 CFR 1910 requirements.
• Experience working in cGMP environments.
• Experience in biochemical, petrochemical, pharmaceutical, energy, oil and gas industries is preferred.
• Experience with engineering simulation tools (e.g. Aspen Plus, ChemCAD, etc.).

USA Sales Manager, Full-Time – Remote – East Coast

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today.

We are seeking a highly motivated Sales Manager with in driving the sales strategies and initiatives of the company throughout the US. You will lead to the Vice President of Global Sales and help, drive sales in the industry. This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative applied to the various duties and aspects of the position. This person will be expected to play an integral part of the organization’s team.

Why work for the company:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that come with working on the cutting edge.

Responsibilities:

Make customer contacts at, research, application development, supply chain, marketing levels with customers and prospective customers. Develop application of products and services in an effective manner. Researching customer needs and developing applications of the company’s products and services in an effective manner by:

• obtaining & coordinating data & information from internal and external stakeholders & member groups
• researching and developing lists of potential customers
• maintaining up-to-date understanding of industry trends and technical developments that effect target customers and markets
• determining market strategies & goals for each client which matches product and service to their strategic objectives

Develop and deliver sales presentations and close sales in a professional and effective manner by:

• developing sales proposals for customers on technical products & services
• developing technical presentations & workshops
• maintaining up-to-date awareness of activities, industry trends & government regulations
• making regular sales calls to develop relationships and follow up on leads
• establishing long-term, ongoing repeat relationships
• attend trade shows as assigned throughout the year to promote product portfolio and develop project initiatives
• meeting established sales quotas and revenue goals
• resolving problems with products and services

Participate in sales forecasting, sales planning, and CRM in an effective timely manner by:

• researching, developing & maintaining long- & short-range sales & marketing plans
• maintaining an up-to-date awareness of strategic plans and procedures to coordinate market plans
• monitoring, analyzing, & communicating monthly sales data to contribute to product/service planning
• Participate in development of new products, modification of existing products in an effective and professional manner by:
• recommending new technical products & product modifications or terminations
• gathering analyzing, and sharing customer technical information & feedback
• working with other staff to identify future customer needs
• determining customer satisfaction with products and services
• maintaining an up-to-date working knowledge of newly developing technologies and manufacturing practices

Develop and maintain communications in a cooperative and professional manner with all levels of staff and customers by:

• communicating openly, honestly and constructively
• treating all employees and customers with dignity, respect and courtesy
• taking responsibility for and making every effort to resolve communication, trust and respect concerns and problems
• Develop and maintain databases relating to research data including product formulations, analytical and sensory data and other project related information” in the company CRM system.

Provide technical support and maintain programs that allow analysis of information.

• Engage in technical discussions with potential clients, demonstrations and presentations.
• Remain knowledgeable and up-to-date on changes and developments within the sweetener industries.
• Keep management informed of all activity, including timely preparation of reports.
• Provide direction in complex problem-solving situations and participate in direct interaction with customers as required.
• Identify process improvement opportunities with customer processes and through communications, programs and other activities as needed, collaborate with the customer to implement improvements.

Required Qualifications:

• B.S. in Food Science, technical or business discipline with a minimum of 7-10 years in a sales role in the flavor or food ingredient industries.
• Technical knowledge of sweetener formulation.
• Strong analytical, problem solving, and negotiation skills.
• Organization and use of CRM database systems.
• Proficient in use of e-mail Word, PowerPoint, and Excel programs.
• Excellent oral/written communication skills, well developed presentation skills, excellent customer relations skills.
• In-depth knowledge of target market industries
• Ability to travel at least 50% of the time
• Ability to influence and persuade to achieve desired outcomes.
• Excellent organizational, planning, and prioritization skills.

Preferred Working Style:

• Ability to think strategically, analyze market data, identify business opportunities, and develop actionable sales plans to drive revenue growth.
• Excellent leadership skills to motivate and inspire the sales team, strong communication and interpersonal skills to build relationships with clients and stakeholders, and the ability to communicate effectively at all levels of the organization.
• Strong analytical skills to analyze sales data, identify trends, and make data-driven decisions. Effective problem-solving abilities to address challenges and drive sales performance.
• Ability to work in a fast-paced, dynamic environment and adapt to changing market conditions.
• Must hold themselves to the highest professional, scientific and ethical standards.

Pilot Plant Fermentation Operator, Augusta, Georgia, United States, Full-Time

Manus works across industries and value chains to accelerate the transition to BioAlternatives - better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today. We are seeking a highly motivated Pilot Plant Fermentation Operator,. This person will be expected to play an integral part of Manus Bio’s manufacturing and process development team located in Augusta, GA.

The Pilot Plant Fermentation Operator is responsible for the continuing efficient operation of the pilot plant. This includes maintenance, equipment reliability, and operations. Creativity and decision-making skills are required. Must be able to maintain a good working relationship with all personnel. Work as a member of the pilot plant team which includes assisting both with fermentation and downstream work assignments. Controls, monitors, and measures processes as instructed. Abides by all safely, environmental, and quality requirements. Perform minor maintenance and duties related to product testing, including sampling.

Why work at Manus Bio:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that come with working on the cutting edge.

Responsibilities:

Interface with process development team to provide resources to solve fermentation and product isolation challenges. Execute and help evaluate experiments. This activity includes:

• Perform downstream purification operations including centrifugation, chromatography (e.g., affinity, ion exchange), filtration (TFF, depth, sterile).
• Set up, operate, and clean process equipment such as columns, tanks, and filtration systems.
• Collect, label, and process in-process and final product samples.
• Monitor process parameters, record data, and ensure batch documentation is completed accurately.
• Perform cleaning and sterilization of equipment and cleanroom areas (CIP/SIP procedures).
• Assist in deviation investigations and continuous improvement initiatives.
• Collaborate with upstream and quality departments to ensure efficient process flow and product quality.
• Maintain inventory of DSP consumables and request resupply as needed.
• Become familiar with all required batch records, execute according to the batch records and ensure clear communication of the targeted design parameters.
• Execute day-to-day Pilot Plant activities, coordinating equipment maintenance and installation activities, troubleshooting process upsets, troubleshooting equipment and instrumentation problems, optimizing operations, addressing contamination issues, addressing downtime or other runtime losses.
• Maintain the upkeep of the Pilot Plant equipment through the process of initiating work notifications/work orders and maintenance scheduling; Be capable of correcting minor maintenance issues.
• Adhere to company environmental, safety, and health policies and procedure. Ensure Pilot Plant compliance with safety and environmental regulations.
• Physical demand requirements are more than sedentary work due to inspection of equipment. Must be able to climb stairs and ladders. Must be able to lift 50 pounds.
• Must be able to wear the required protective equipment, including respirators when needed.
• Work schedule is considered shift but will vary depending on manufacturing plan and other extraordinary conditions.

Required Qualifications:

• High school diploma or GED equivalent.
• Minimum of 3 years downstream or related plant operator experience.
• Must be able to follow minimal instructions and support safe work practices.
• Must be an excellent team member with strong communication skills and a desire to work collaboratively.
• Must be flexible with day-to-day duties and able to thrive in a start-up environment.
• Must hold themselves to the highest professional and ethical standards.
• Some familiarity with the production fermentation and downstream processes and equipment as well as microbiological and analytical laboratory procedures.
• Demonstrates flexibility in job rotations/various assignments.
• Basic PC skills which include Windows, Microsoft Office.

:

• SAP skills
• Certified Train the Trainer skills
• Delta V controls experience

Pilot Plant Downstream Processing Operator

Manus

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today. We are seeking a self-motivated and highly organized individual for a position that will specialize in laboratory operations at our Augusta BioFacility.

Why work at Manus:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Responsibilities:

• Interface with process development team to provide resources to solve fermentation and product isolation challenges. Execute and help evaluate experiments. This activity includes:
• Perform downstream purification operations including centrifugation, chromatography (e.g., affinity, ion exchange), filtration (TFF, depth, sterile).
• Set up, operate, and clean process equipment such as columns, tanks, and filtration systems.
• Collect, label, and process in-process and final product samples.
• Monitor process parameters, record data, and ensure batch documentation is completed accurately.
• Perform cleaning and sterilization of equipment and cleanroom areas (CIP/SIP procedures).
• Assist in deviation investigations and continuous improvement initiatives.
• Collaborate with upstream and quality departments to ensure efficient process flow and product quality.
• Maintain inventory of DSP consumables and request resupply as needed.
• Become familiar with all required batch records, execute according to the batch records and ensure clear communication of the targeted design parameters.
• Execute day-to-day Pilot Plant activities, coordinating equipment maintenance and installation activities, troubleshooting process upsets, troubleshooting equipment and instrumentation problems, optimizing operations, addressing contamination issues, addressing downtime or other runtime losses.
• Maintain the upkeep of the Pilot Plant equipment through the process of initiating work notifications/work orders and maintenance scheduling; Be capable of correcting minor maintenance issues.
• Adhere to company environmental, safety, and health policies and procedure. Ensure Pilot Plant compliance with safety and environmental regulations.
• Physical demand requirements are more than sedentary work due to inspection of equipment. Must be able to climb stairs and ladders. Must be able to lift 50 pounds.

Working Hazards and Conditions:

• This position involves work on the third floor of the facility and requires occasional manual handling of hazardous materials, including carrying pitchers of sulfuric acid and glassware (such as beakers, flasks, and similar lab equipment).
• The role also involves working around hot steam tanks, requiring strict adherence to safety procedures and use of appropriate personal protective equipment (PPE) at all times.
• At certain times, the employee may be required to work alone, necessitating compliance with Manus Bio’s lone worker safety protocols to ensure proper communication and emergency preparedness.
• Employees must maintain a heightened awareness of their surroundings, follow all established chemical handling and steam safety procedures, and participate in mandatory hazard and emergency response training.
• Must be able to wear the required protective equipment, including respirators when needed.
• Work schedule is considered shift but will vary depending on manufacturing plan and other extraordinary conditions.

Required Qualifications:

• High school diploma or GED equivalent.
• Minimum of 3 years downstream or related plant operator experience.
• Must be able to follow minimal instructions and support safe work practices.
• Must be an excellent team member with strong communication skills and a desire to work collaboratively.
• Must be flexible with day-to-day duties and able to thrive in a start-up environment.
• Must hold themselves to the highest professional and ethical standards.
• Some familiarity with the production fermentation and downstream processes and equipment as well as microbiological and analytical laboratory procedures.
• Demonstrates flexibility in job rotations/various assignments.
• Basic PC skills which include Windows, Microsoft Office.

Preferred Qualification and Working Style:

• SAP skills
• Certified Train the Trainer skills
• Delta V controls experience

Manufacturing Excellence Lead Augusta, Georgia, United States, Full-Time

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of synthetic biology today. We are seeking a self-motivated and highly organized individual for a position that will specialize in and lead all laboratory operations at our Boston BioFacility.

We are looking for a Manufacturing Excellence Head to lead and institutionalize manufacturing excellence across operations. This role will be responsible for driving structured improvements in reliability, efficiency, and process performance through a disciplined, pillar-based approach.

Why work at Manus:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.

Key Responsibilities:

Serve as manufacturing plant lead, overseeing daily operations. Develop and lead a structured continuous improvement (CI) program across manufacturing, formally categorizing and managing all initiatives under three core pillars:

Hygienic Design Leadership

• Drive improvements in equipment design, cleanability, and sanitary engineering. Eliminate harborage points and ensure alignment with hygienic design standards to enhance product quality, reduce contamination risk, and improve clean-in-place (CIP) effectiveness

Consistent Operations Excellence:

• Establish and enforce standard work, process discipline, and operational rigor. Ensure robust SOP adherence, operator training programs, and repeatable execution of manufacturing processes to minimize variability and improve reliability.

Manufacturing Process Improvements:

• Lead yield optimization, cycle time reduction, waste elimination, process capability enhancement, technical upgrades, and new product startups.
• Define, implement, and monitor KPIs (OEE, yield, cycle time, downtime, batch success rate). Lead manufacturing data and stats preparation and reporting activities. Utilize data analytics to identify losses and track impact. Partner with Manufacturing, Quality, Engineering, Maintenance, and Process Technology teams to align initiatives to meet business objectives

???????Qualifications

• Bachelor’s degree in Engineering, Manufacturing, or related field (Master’s preferred).
• 5–10 years in manufacturing with focus on continuous improvement (CI), operational excellence, or reliability.
• Proven experience implementing Lean, Six Sigma, TPM, or similar methodologies.
• Strong understanding of hygienic design principles and GMP environments preferred.
• Demonstrated ability to lead cross-functional initiatives and drive measurable improvements.
• Strong analytical, problem-solving, and data-driven skills.
• Excellent communication, leadership, and organizational skills.
• Experience with manufacturing systems, data analytics, process control, AI/IIoT a plus.

Preferred Qualifications

• Lean Six Sigma Certification (Green Belt, Black Belt, or higher).
• Experience in biomanufacturing, food, pharmaceutical, or chemical industries.
• Proven track record building and sustaining CI programs at scale.

Quality Technician, Augusta, Georgia, Full-time, Contract

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of biotechnology today.

Manus is seeking a detail-oriented Quality Technician (Contractor) to support day-to-day quality control (QC) testing and quality assurance (QA) plant audit activities at our food-ingredient manufacturing site. Working under the direction of the Quality team, the technician performs sampling and routine analytical and in-process testing, documents results accurately and assists with GMP and food-safety audits across the plant. This is a hands-on role well suited to someone with strong attention to detail, sound documentation discipline, and a genuine commitment to safety and quality.

Why work at Manus:

• Opportunity – For motivated, results-oriented team members, our growth creates opportunities for personal and professional advancement.
• Accountability – You are given the resources you need to succeed and the freedom to make it happen; in return, we hold each other accountable for our high expectations.
• Passion – We love what we do and enjoy working with others who feel the same way. We embrace the challenge and hard work that comes with working on the cutting edge.
  

Key Responsibilities

Quality Control (QC) Support

• Sampling — Collect and prepare raw-material, in-process, finished-product, and environmental samples per established procedures.
• Routine testing — Perform routine QC and in-process tests (e.g., pH, moisture, density, conductivity, appearance) and basic instrument checks.
• Documentation — Record and verify results accurately in logbooks / LIMS and promptly flag out-of-specification (OOS) results to QC staff.
• Environmental monitoring — Support environmental monitoring (EMP) and ATP sampling and the associated documentation.
• Lab readiness — Maintain lab cleanliness, calibration and reagent logs, supply inventory, and instrument readiness.
• Sample handling — Assist with retain-sample management and stability-sample handling.
• Good practice — Follow Good Laboratory Practice (GLP), GMP, and all safety requirements.

Quality Assurance (QA) Audit Support

• Audit walkthroughs — Assist QA in conducting GMP and food-safety walkthroughs and audits across the plant.
• Findings capture — Complete inspection checklists, capture findings and photos, and compile audit observations.
• Corrective actions — Support documentation of corrective actions and follow-up verification.
• Records — Help maintain audit records, logs, and the master sanitation / inspection schedule.
• Audit readiness — Support preparation for customer, third-party, and regulatory audits.

Required Qualifications

• High school diploma or equivalent; Associate’s degree or B.S. in a science discipline preferred.
• 1+ years of experience in a QC, laboratory, or quality role — ideally in food, beverage, pharmaceutical, or chemical manufacturing.
• Familiarity with basic laboratory testing techniques and instruments.
• Strong attention to detail with accurate documentation and record-keeping.
• Ability to read and follow SOPs and to apply GMP and food-safety practices.
• Basic computer skills (data entry, spreadsheets); LIMS experience a plus.
• Good communication skills and the ability to work effectively within a team.

Preferred Qualifications

• Associate’s degree or B.S. in chemistry, biology, food science, or a related field.
• Experience in cGMP / FSMA, HACCP, or GFSI (SQF / BRC) environments.
• Hands-on experience with environmental monitoring, ATP, titrations, or HPLC sample preparation.
• Exposure to audits and CAPA documentation.

Scope & Working Conditions

• Engagement — Contract position (initial term [6–12 months], with potential to extend); hourly, non-exempt.
• Reporting — Reports to the [QC Supervisor / QA Manager] and works alongside the on-site Quality team.
• Location & schedule — On-site in Augusta, GA; may require shift or weekend coverage based on production needs.
• Physical demands — Combination of laboratory and plant-floor work; standing for extended periods, lifting up to ~25 lbs., and use of appropriate PPE.

Research Associate / Senior Research Associate – Strain and Enzyme Engineering-Waltham, MA

Manus works across industries and value chains to accelerate the transition to BioAlternatives – better performing and more sustainable versions of complex molecules traditionally sourced from plants, animals, or fossil fuels. Our platform is proven to work across scales, bridging the Valley of Death between lab and manufacturing more efficiently and more reliably to deliver the benefits of biotechnology today.

Manus is seeking a Research Associate (RA) or Senior Research Associate (SRA) to support strain engineering and analytics workflows within our project pipeline. In this role, you will design and construct plasmids, generate chromosomally integrated Escherichia coli (E. coli) strains, culture and screen engineered strains, and process the resulting analytical data (liquid extraction, Gas Chromatography (GC) and/or Liquid Chromatography (LC)) to identify strains with enhanced performance. This role focuses on execution of defined engineering campaigns to drive meaningful improvements in a fast-paced, cross-functional environment.

This hands-on position requires a desire and ability to work as an integral part of a multidisciplinary team, as well as the demonstration of a high degree of flexibility, creativity, and initiative. This person will be expected to play an integral part of Manus’s research and development team located in Waltham, Massachusetts (MA).

Responsibilities

Molecular biology: Design, construct, and validate plasmids for gene expression and pathway engineering in microbial hosts.

Strain construction: Generate chromosomally integrated E. coli strains (e.g., via recombineering or CRISPR-based methods) to support strain engineering campaigns.

Strain cultivation: Culture and maintain engineered E. coli strains in solid and liquid formats at lab scale.

Sample preparation: Perform liquid-liquid or solid-phase extraction of fermentation broth and other sample matrices to prepare samples for analytical testing.

Analytical execution: Operate GC and/or LC instrumentation to generate quantitative data on strain performance (e.g., titer, yield, product profile).

Data analysis: Process, QC, and interpret analytical and strain-performance data; summarize and present findings to the project team.

Data management: Ensure accurate data collection, processing, and upload to LIMS systems.

Collaboration: Collaborate with cross-functional teams (molecular biology, fermentation, downstream processing) to improve experimental outcomes.

Lab operations: Maintain instrumentation readiness and general lab organization.

Documentation: Author and update SOPs and experimental documentation.

Basic Qualifications

• Research Associate: Bachelor’s degree with 0–4 years’ relevant experience.
• Senior Research Associate: Bachelors with 4–7 years’ or master’s with 2–4 years’ relevant experience.
• Degree in molecular biology, biochemistry, microbiology, chemistry, bioengineering, or a related field (field of degree is flexible; relevant hands-on experience is prioritized).
• Hands-on experience with plasmid design and cloning (e.g., Gibson assembly, Golden Gate, restriction/ligation).
• Experience culturing and screening engineered microbial strains in liquid and/or solid formats.

Preferred Skills

• Direct experience generating chromosomal integrations in E. coli specifically (e.g., lambda Red recombineering, CRISPR-based integration).
• Experience with LIMS systems (e.g., Benchling).
• Data analysis and visualization experience (e.g., JMP, Python, SQL).
• Familiarity with GC-MS or LC/MS (mass-selective detection) in addition to GC-FID or standard LC/UV-Vis workflows.
• Experience with sample extraction (liquid-liquid or solid-phase) from biological or fermentation matrices.
• Experience with automated liquid-handling systems.

Physical Requirements

• Ability to work in industrial environments.
• May require standing, walking, climbing stairs, and lifting equipment up to 50 lbs.
• Use of PPE required in designated areas.