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IT Support Specialist Iambic Therapeutics · San Diego, California, United States $75k–94k 67 days ago On-site Engineering

Associate Director / Director, Regulatory Affairs - CMC Iambic Therapeutics · San Diego, California, United States $164k–245k 71 days ago On-site Engineering

Machine Learning Scientist – Clinical Prediction Iambic Therapeutics · Boston, MA, US $148k–186k 128 days ago Remote Engineering

Research Scientist II/Senior, Discovery Machine Learning Iambic Therapeutics · San Diego, California, United States $146k–204k 131 days ago On-site Engineering

Machine Learning Scientist — Agentic data pipelines Iambic Therapeutics · Boston, MA, US $148k–210k 171 days ago Hybrid Engineering

Machine Learning Scientist — Large multimodal models Iambic Therapeutics · Boston, MA, US $148k–210k 171 days ago Hybrid Engineering

Engineering

128 days ago

Machine Learning Scientist – Clinical Prediction

Iambic Therapeutics · Boston, MA, US

Pay

$148k–186k

Setting

Remote

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JOB SUMMARY We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. In this role, you will design and implement clinical fine-tuning of Enchant, our multimodal transformer model trained on a wide variety of biomedical data, pushing the boundaries of what large-scale foundation models can achieve in drug discovery. This role spans data sourcing through to production deployment. You will identify, curate, and evaluate datasets that support prediction of relevant clinical endpoints (patient- and trial-level outcome modeling, safety/toxicity prediction, and PK/PD response modeling) and fine-tune Enchant to deliver critical clinical insights. This includes developing rigorous, leakage-resistant experimental frameworks, optimizing training, orchestrating runs at scale, and working with colleagues across ML and clinical functions to put these models into the hands of scientists making real therapeutic decisions. KEY RESPONSIBILITIES - Fine-tune large-scale multimodal transformer models for clinical and biomedical applications - Identify, characterize, and utilize datasets that can deliver insights into pharmacokinetics (PK), pharmacodynamics (PD), toxicity, clinical adverse events, and clinical trial outcomes - Develop and apply rigorous experimental approaches that account for multiple sources of potential leakage (split, metadata, trial-family, temporal, ontological, arm-comparator, etc.) - Design and maintain benchmarking and evaluation frameworks that track model quality across models and tasks - Build models with appropriate calibration, uncertainty quantification, and clinically meaningful evaluation metrics. - Collaborate with ML and software engineering colleagues to deploy and operationalize models - Partner with clinical scientists and pharmacologists to ensure model development is grounded in drug discovery and development needs - Communicate results to internal teams, external partners, and at conferences - Generate high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity REQUIRED QUALIFICATIONS - MS in chemistry, bio/chemical engineering, or a computational STEM field with 3+ years of relevant industry or research experience, or PhD or equivalent industry experience demonstrating comparable depth - Strong Python experience, including implementing and fine-tuning deep learning models - Demonstrated experience in clinical science or working with clinical datasets - Excellent Data Science skills (problem framing, data sourcing, extraction, cleaning, visualization, EDA, modeling, tuning, storytelling, etc.) - Enough independence to own a workstream from data ingestion through evaluation - Strong engineering habits: reproducible experimentation, appropriate control strategy, clean code, testing - Comfort working with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking such as Weights & Biases) PREFERRED QUALIFICATIONS - Experience building and deploying clinically relevant prediction models - Familiarity with ClinicalTrials.gov/AACT http://ClinicalTrials.gov/AACT data - Experience with MedDRA, pharmacovigilance, or adverse event data - Direct exposure to multi-task learning - Hands-on experience with agentic data extraction - HPC or large-scale computing experience ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai. MISSION & CORE VALUES Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies. PAY AND BENEFITS We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.

Listed by Iambic Therapeutics for a position based in the United States. Employers on this board attest they are hiring domestically.

Engineering

131 days ago

Research Scientist II/Senior, Discovery Machine Learning

Iambic Therapeutics · San Diego, California, United States

Pay

$146k–204k

Setting

On-site

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JOB SUMMARY We are seeking skilled scientists to join our Discovery Machine Learning group at Iambic Therapeutics. In this role, you will be a key player in applying advanced ML techniques to support our drug discovery efforts and will be part of drug discovery teams pursuing important therapeutics across multiple indications. The work will include focus on our flagship machine learning models, including Enchant, our multimodal transformer model for predicting drug-target interactions and molecular properties. This role is based at our San Diego headquarters. KEY RESPONSIBILITIES - Train, fine-tune, and evaluate machine learning models, assessing how they can best be leveraged in a drug-discovery setting and optimizing their performance - Partner with computational chemists, medicinal chemists and biologists to leverage ML insights for decision-making in high-throughput design-make-test-analyze cycles - Generate value, internally and for partners, from our machine learning models, and collaborate with other discovery teams to shape their use - Communicate results with internal drug discovery teams and machine learning scientists and externally with partners - Support the evolution of our machine learning models by gathering analytical feedback and delivering domain-driven guidance to the machine learning team QUALIFICATIONS Required: - PhD or equivalent degree in chemistry or another physical science with 3+ years of experience or commensurate degree and job experience. More junior candidates are welcome to apply, title will reflect experience. - Familiarity with using statistical analysis techniques to evaluate, troubleshoot, and adapt models in scientific contexts - Excellent written and verbal communication skills; must be able to articulate complex scientific concepts, technical challenges, and results clearly and concisely to diverse audiences. - Skills: Python programming, statistics, drug discovery Strongly preferred: - PhD or equivalent degree in computational chemistry or machine learning in chemistry - 3+ years of experience working in a drug discovery project ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai. MISSION & CORE VALUES Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies. PAY AND BENEFITS We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.

Listed by Iambic Therapeutics for a position based in the United States. Employers on this board attest they are hiring domestically.

Engineering

171 days ago

Machine Learning Scientist — Agentic data pipelines

Iambic Therapeutics · Boston, MA, US

Pay

$148k–210k

Setting

Hybrid

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Job Summary We are seeking a scientist to join our team at Iambic Therapeutics, working on data acquisition and curation for Enchant https://www.iambic.ai/post/enchant, our multimodal transformer model trained at scale on a wide variety of biomedical data. In this role, you will design and build agentic systems that acquire, clean, format, and quality-control the large-scale datasets that power Enchant training. You will work at the intersection of LLM-based automation and biomedical data engineering—developing AI agents that can navigate heterogeneous data sources, enforce quality standards, and operate reliably at scale. This role is ideal for candidates who combine strong software engineering instincts with scientific understanding of biomedical data, and who are excited about using LLMs as tools to solve practical data problems. Key Responsibilities - Design, build, and maintain agentic systems for automated data acquisition from public and proprietary biomedical data sources - Develop LLM-based pipelines for data cleaning, normalization, and formatting across diverse data modalities (e.g., molecular, genomic, clinical, literature) - Implement automated quality-control workflows that detect anomalies, flag inconsistencies, and enforce data standards - Evaluate and iterate on agent architectures, prompting strategies, and tool-use patterns to improve reliability and throughput - Collaborate with ML scientists on the Enchant team to understand data requirements and translate them into scalable acquisition and processing systems - Monitor and maintain data pipelines in production, diagnosing failures and improving robustness over time - Document data provenance, processing decisions, and quality metrics to support reproducibility and auditing Qualifications Required: - Master's or PhD in a computational STEM field, or equivalent industry experience - Strong Python engineering skills, including experience building and maintaining production-quality software - Hands-on experience with LLM APIs (e.g., Claude, GPT) and agentic patterns such as tool use, orchestration, and multi-step reasoning - Familiarity with biomedical or chemical data sources and formats (e.g., PDB, UniProt, ChEMBL, SDF/MOL, FASTA, or similar) - Comfort with data engineering fundamentals: ETL design, data validation, and working with structured and unstructured data at scale Desired: - Experience with agent orchestration frameworks - Familiarity with cloud infrastructure and workflow orchestration (e.g., AWS, Docker, Kubernetes) - Knowledge of multimodal biomedical data—spanning small molecules, proteins, assays, images, ‘omics, and/or clinical records - Experience with large-scale dataset construction or curation for ML model training Location Remote (US or UK). On-site available in Bristol, UK and Boston, US. ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai. MISSION & CORE VALUES Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies. PAY AND BENEFITS We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.

Listed by Iambic Therapeutics for a position based in the United States. Employers on this board attest they are hiring domestically.

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