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JOB SUMMARY We are seeking a Senior or Executive Medical Director to provide medical and clinical development leadership for our early-stage oncology portfolio. This individual will own the clinical strategy and execution for one or more assets from IND-enabling activities through first-in-human and early efficacy studies. You will serve as the clinical and scientific lead on cross-functional program teams, working closely with our discovery, translational, regulatory, and clinical operations groups — and directly alongside our AI/ML platform teams — to translate novel candidates into well-designed clinical programs. This position will be based in our San Diego Headquarters. Title and scope will be calibrated to the successful candidate's experience. KEY RESPONSIBILITIES - Serve as the clinical/medical lead for early-stage oncology programs, owning the clinical development strategy from IND through Phase 1 and early proof-of-concept. - Author and drive the clinical components of IND submissions, including protocols, investigator's brochures, and clinical sections of regulatory documents; support and participate in health authority interactions (e.g., pre-IND, EOP1). - Design first-in-human and early-phase oncology trials, including dose-escalation and dose-optimization strategies, biomarker and translational plans, and eligibility criteria. - Provide ongoing medical monitoring and safety oversight for active trials, including review of emerging safety data, dose decisions, and management of study conduct in partnership with Clinical Operations and Pharmacovigilance. - Partner with translational science and the AI/ML platform teams to define patient selection strategies, pharmacodynamic endpoints, and data-driven development hypotheses. - Engage key opinion leaders, investigators, and study sites; represent programs to internal governance, partners, and, as appropriate, external stakeholders. - Collaborate cross-functionally with Regulatory Affairs, CMC, Clinical Operations, Biostatistics, and Program Management to keep programs on strategy and on timeline. - Contribute to portfolio-level decisions, candidate selection input, and business development / due diligence as needed. QUALIFICATIONS - M.D. or D.O. (or international equivalent); board eligibility/certification in hematology/oncology or medical oncology strongly preferred; exceptional candidates with PharmD and relevant oncology and clinical experience will be considered - Meaningful drug-development experience in biotech or pharma. We anticipate roughly 5+ years for a Senior Medical Director and 8–10+ years for an Executive Medical Director; strong candidates across this range are encouraged to apply. - Direct, hands-on experience authoring and executing IND submissions. - Direct experience designing and running Phase 1 / early-phase oncology clinical trials. - Demonstrated experience with oncology assets and a strong understanding of the oncology therapeutic and drug-development landscape. - Working knowledge of GCP, ICH guidelines, and the global regulatory environment for oncology development. PREFERRED QUALIFICATIONS - Experience with small-molecule oncology programs and targeted therapies. - Experience taking a program from candidate nomination or IND through clinical proof-of-concept. - Comfort working in a fast-paced, data-rich, technology-forward environment and collaborating with computational and platform teams. - Prior experience presenting to health authorities and/or supporting BD due diligence ABOUT IAMBIC THERAPEUTICS Iambic is a clinical-stage life-science and technology company developing novel medicines using its AI-driven discovery and development platform. Based in San Diego and founded in 2020, Iambic has assembled a world-class team that unites pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated delivery of new drug candidates to human clinical trials with unprecedented speed and across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and in partnership, to address urgent unmet patient need. Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai http://iambic.ai. MISSION & CORE VALUES Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies. PAY AND BENEFITS We offer industry leading competitive pay, company paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation to our team. We are in a brand-new state-of-the art facility in beautiful San Diego with an onsite gym, dining, and easy access to great places to live and play.

Listed by Iambic Therapeutics for a position based in the United States. Employers on this board attest they are hiring domestically.

Science

33 days ago

Director, Antibody Discovery

BigHat Biosciences · San Mateo, CA, US

Pay

$220k–250k

Setting

On-site

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Careers at Director, Antibody Discovery The Role: BigHat is seeking an exceptional and highly experienced individual for a position as Director of Antibody Discovery. This individual will lead the company’s antibody discovery and display function. They will be responsible for conceiving of and leading multi-year team and technology strategy as well as managing routine operational execution for identification and maturation of high-quality antibodies across antigen types for both BigHat and BigHat-partnered therapeutic research programs. Key Responsibilities Lead BigHat’s antibody discovery and display functions, setting the scientific, technical, and strategic direction Oversee the routine execution of display-based selection campaigns to enhance and diversify affinity, developability, and function across diverse antibody formats and antigen types in support of BigHat and BigHat-partnered therapeutic programs Manage and mentor a team of scientists responsible for antibody library design, generation, screening, selection, and early optimization Shape and expand BigHat’s antibody discovery technologies and capabilities, including new display and selection methods, library design strategies, and technical approaches that leverage and enhance the company’s integrated experimental and computational platform Provide scientific leadership across discovery and early optimization efforts, ensuring antibodies emerging from selections possess strong functional and developability characteristics Work closely with leaders in Protein Sciences, Data Science/Machine Learning, Engineering, and Platform groups to ensure seamless progression from discovery through characterization and optimization Collaborate with biology and therapeutic research leads to ensure display outputs align with and advance program objectives Foster a collaborative and high-performance culture within the discovery organization Skills Knowledge and Expertise Ph.D. in molecular biology, biochemistry, protein engineering, or related discipline with 10+ years of experience in antibody discovery and engineering within academia, biotechnology, or pharmaceutical industries 5+ years of managerial experience leading scientific teams Strong expertise with protein display systems such as yeast, phage, mammalian, or mRNA display Demonstrated experience with antibody library design, construction, screening, and selection analysis Deep understanding of antibody structure-function relationships and mechanisms of antigen recognition Experience integrating antibody discovery workflows with downstream characterization and developability assessment, including functional screening and biophysical evaluation of antibody candidates Familiarity with computational or ML-enabled approaches to protein design and optimization Experience advancing biologics from early discovery through lead optimization stages Knowledge of diverse antibody modalities including multispecific antibodies, antibody fragments, and other advanced formats Strong leadership skills with experience building and mentoring scientific teams Strategic thinker capable of aligning discovery activities with broader company goals Excellent communication and cross-functional collaboration skills Self-motivated and comfortable working in a fast-paced startup environment Must be willing to work onsite 5 days per week Total Rewards The salary estimated for this position is $220,000 - $250,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer. What BigHat Offers: Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived) Dental, and vision coverage through Guardian Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more 401(k) with company match DTO, two weeks of company-wide shutdown, and 12 company holidays Paid parental leave About BigHat Biosciences BigHat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. BigHat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these design capabilities to develop new generations of safer and more effective treatments for patients suffering from today’s most challenging diseases. BigHat is a Series B biotech outside San Francisco with a team-oriented, inclusive, and family-friendly culture. Our broad pipeline of wholly-owned and partnered therapeutic programs span many disparate indications with high unmet need, such as cancer, inflammation, and infectious disease. BigHat has raised >$100M from top investors, including Section 32, a16z, and 8VC. Apply Now Our Hiring Process Stage 6: Full Panel Interview Stage 7: Offer (Pending References) Stage 8: References Stage 9: Hired Stage 1: Applied Stage 2: Initial Conversation | Head of Talent Stage 3: Initial Conversation | Hiring Manager Stage 4: 1st Technical Screen Stage 5: 2nd Technical Screen Stage 6: Full Panel Interview Stage 7: Offer (Pending References) Stage 8: References Stage 9: Hired Stage 1: Applied Stage 2: Initial Conversation | Head of Talent Stage 3: Initial Conversation | Hiring Manager Stage 4: 1st Technical Screen Stage 5: 2nd Technical Screen Stage 6: Full Panel Interview Stage 7: Offer (Pending References) Stage 8: References Stage 9: Hired 1 2 3 Not quite right? Register your interest to be notified of any roles that come along that meet your criteria. Register Your Interest Apply Now Department Lab Science Employment Type Full Time Location San Mateo, CA Workplace type Onsite This role's hiring manager: Charbel Eid View Charbel's Profile View all opportunities at BigHat Biosciences BIGHAT BIOSCIENCES PRIVACY POLICY COOKIES POWERED BY Cookies We use cookies to ensure you get the best experience on our website. Accept all Reject all Settings

Listed by BigHat Biosciences for a position based in the United States. Employers on this board attest they are hiring domestically.

Science

33 days ago

Research & Thought Leadership Lead

AirOps ·

Pay

$125k–295k

Setting

Remote

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ABOUT AIROPS AirOps is the full-service platform for brand growth in the age of AI search. As consumers shift from traditional search engines to platforms like ChatGPT, Claude, and Gemini, the entire ruleset of growth is being rewritten. Buyers now rely on agents to discover, recommend, and purchase products and services for them. If your brand isn't part of the answer, you aren't in the running. Our platform offers everything a brand needs to get found, recommended, and earn trust. We work with category leaders, including teams at Ramp, Chime, Airbnb, ServiceNow, and Rippling, to drive visibility and accelerate growth from AI search. Backed by Greylock, Unusual Ventures, Wing VC, and Founder Collective, we're headquartered in San Francisco, New York, and Montevideo. ABOUT THE ROLE: We’re looking for a marketing leader who can take AirOps’ existing research foundation and build on it, creating a brand that’s known for being one step ahead of what’s happening in the industry and that marketers across industries and disciplines turn to and trust for its data-driven story telling. There’s no shortage of data: AirOps has millions of data points and search queries we track on a daily basis. What we need is someone who can find the interesting story in that data and turn it into high-quality, frontier content and research. This role is a blend of thought leadership, research, and brand, and we’re looking for someone who has the ability to run the analysis and the taste to know what’s worth publishing. You’ll work directly with our executive team to set the direction for our thought leadership program, then partner across the org to turn research and insights into campaigns and programs that drive brand awareness, capture the attention of senior buyers, and help every marketer stay ahead of what’s coming next. This is a high visibility, high impact role with the ability to shape our brand, tell impactful stories, and see the impact of your work every day. WHAT YOU’LL DO - Set our thought leadership program and direction: Work directly with our CEO and CMO to set the tone, direction, and strategy for our research and thought leadership program - Determine the data worth digging into: You’re plugged in enough to know what is on our audience’s mind, and what hasn’t broken through yet, and can pair that with a strong point of view on the data we should be looking at to find the next story to tell. You’re not waiting for someone to tell you what stories to write, you’re deeply curious and have a backlog of data you want to dig into. - Source and run your own research: You might not be a classically trained researcher, but you know your way around Claude Code and can learn quickly to be able to field expert surveys, query first-party product and usage data directly, and build a real point of view from raw findings, without needing to hand that work to an outside research partner. - Build a program around research: Turn insights and thought leadership content into cross-channel campaigns and brand awareness. Work across product, events, design, product marketing, paid, and organic to create tentpole “moments” around our research that amplify our brand and point of view beyond our existing audience. - Connect research to strategy: Partner closely with product and sales leaders to understand our product roadmap and target buyers, then build plans to launch research that underscores the importance of each product we launch or industry we break into - Social distribution: Own our overall voice, tone, and cadence for research-focused social posts and content. We’re looking for someone who doesn’t want to just drive thought leadership, they want to help build our brand and voice. - Our quality bar: The quality of our thinking is reflective of the quality of the work we’ll provide to our customers. This role should be the arbiter of our quality bar, moving with urgency but making sure nothing you ship looks rushed. WHO YOU ARE - 7+ years of experience in thought leadership, content marketing, research, or equivalent. - Experience working with data: You’ve produced research reports, insights surveys, and data-driven storytelling before. You know how to dig into data and find the insight from it. - Experience with, and excitement to dig into, deep datasets: We’re looking for someone who’s excited to get into Claude Code, find a data set, and figure out how to get the insights they need. You’ll have resources you can tap, but the goal is to have someone who can run on their own. - Proven experience running cross-channel marketing campaigns: You can take a piece of content and turn it into a full campaign, spanning across paid, organic, and in-person channels, and enable our customer-facing teams on how to use this data in their conversations - Strong brand point of view: You’ve got opinions on what a great brand looks like, and want to help continue to shape and refine ours. - Experience with corporate and founder social: This role should help shape how we show up on social channels and how our thought leadership breaks through the noise. ABOUT YOU - You love a blank slate and are excited to come in and champion this program. The idea of taking this on immediately gets your wheels turning with ideas. - You obsess over quality and storytelling. You aren’t interested in shipping something unless you truly think it adds to the conversation. - You’ve got 20 newsletters you read a week and are always trying to keep up to date with the latest developments, market shifts, and opinions in the space. Being able to spot a shift before the rest of the industry catches on is a point of pride for you. - You’re high-agency and hands-on. The idea of doing both strategy and execution sounds fun and you love rallying a team behind an initiative. - You love working across marketing, sales, and customer teams and see yourself as someone who breaks down silos in an org to get everyone working together. OUR GUIDING PRINCIPLES 1. Extreme Ownership 2. Quality 3. Curiosity and Play 4. Make Our Customers Heroes 5. Respectful Candor BENEFITS - Equity in a fast-growing startup - Competitive benefits package tailored to your location - Flexible time off policy - Parental Leave - A fun-loving and (just a bit) nerdy team that loves to move fast!

Listed by AirOps for a position based in the United States. Employers on this board attest they are hiring domestically.

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