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Process Design Engineer
Hyfé Foods · San Francisco, CA
Pay
$95k–205k
Setting
On-site
Hyfé
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Process Design Engineer
Research and Development
Full-time
San Francisco, CA
Location: San Francisco, CA
Travel: ~15–20% for pilot work, vendor trials, and partner visits
Reports to: CTO
Position Overview:
Hyfé is seeking a process development engineer who will turn lab and pilot data into decision-ready process models. This role is designed for someone who learns quickly, embraces ambiguity, and is motivated to build scalable, sustainable solutions to some of the world’s most pressing problems.
Role Responsibilities:
Data and analysis. You will own the flow of data from the lab and pilot to process design. You will reconcile and close mass and energy balances, investigate outliers, and document underlying assumptions, such that the data is reliable and defensible for design and economic decisions.
Process modeling and economics. You will build and maintain an Aspen Plus flowsheet with appropriate property methods for aqueous, electrolyte, and biopolymer streams. You will translate model outputs into techno-economic inputs (yields, utilities, throughput, consumables), run focused sensitivity analyses, and summarize what matters for decisions.
Experiment design and scale-up. You will collaborate with chemists to design lean experiments that reduce uncertainty in process performance and product quality. You will engage with equipment suppliers to size and cost unit operations and to plan targeted trials.
Process design and documentation. You will draft and iterate PFDs, P&IDs, control notes, and operating procedures that reflect pilot learning and safety considerations. You will contribute to risk reviews such as structured risk registers (FMEA) and pre-HAZOP activities.
Communication and external deliverables. You will write concise decision memos and prepare clear slides for leadership, investors, and customers. You will contribute figures and process descriptions to support patent and grant applications.
Requirements:
BA in Chemical Engineering or a closely related field with 4+ years of experience
Demonstrated hands-on problem solving in a startup, or similarly fast-paced environment.
Ability to perform mass- and energy-balance reconciliation on imperfect data and to explain the accuracy and precision of common analytical methods (e.g. HPLC, UV-Vis).
Proficiency with process-modeling tools such as Aspen Plus or SuperPro Designer, including justification of property-method selection and definition of pseudo-components for complex streams.
Proficiency in techno-economic modelling (TEM), including running sensitivity and uncertainty analyses, and communicating key cost and risk drivers.
Clear, concise written communication, strong organization, and the ability to present recommendations that enable timely decisions.
Preferred Qualifications:
PhD in Chemical Engineering or closely related field with 1-4 years of experience
Experience building an Aspen Plus model for aqueous or electrolyte systems and translating model outputs into economic evaluations.
Working knowledge of experimental design; sensitivity analysis or simple Monte Carlo methods; and data analysis in JMP, Python, or similar tools.
Experience with biomass preprocessing (for example, milling and solids handling), membranes, filtration, centrifugation, evaporation, or ion-exchange resins.
Experience drafting process diagrams and participating in structured risk identification.
Benefits:
Competitive annual salary, commensurate with experience
15 days PTO, paid holidays, and year-end office closure (pending business performance)
401(k) plan
Comprehensive health benefits, including medical, dental, and vision insurance
Short-term disability coverage
In-office snacks & drinks
About Hyfé:
See our coverage from the World Economic Forum here.
Every year, approximately one billion tons of nutrient-rich fruit and vegetable waste is discarded or under-utilized across global food systems. For processors, getting rid of this waste is costly and emissions-intensive, creating significant environmental impact with little to no economic return. Yet these waste streams contain valuable compounds that could transform the economics of businesses across the food system and help catalyze the production of sustainable chemicals and materials. Hyfé exists to change that.
Hyfé transforms food waste into high-value ingredients using a label-friendly, thermochemical refining process. Our products range from bioactives to fibers, and are being commercialized to make the food we eat healthier for people and the planet. Our team of scientists and engineers brings decades of expertise from the oil refining and chemical industries, specializing in scaling industrial processes and pioneering sustainable solutions.
At Hyfé, you’ll have the opportunity to build at the earliest stages of a mission-driven company—working alongside a world-class team, shaping real products, and helping define how the next generation of ingredients are made.
Our mission is simple: To transform carbon we waste into carbon we need.
____________________________________________________________________________
Hyfé is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other characteristic protected by law.
Posted on July 30, 2026
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Co-op - Research & Development
Hyfé Foods · San Francisco, CA
Pay
$40k–125k
Setting
On-site
Hyfé
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Co-op - Research & Development
Research and Development
Internship
San Francisco, CA
Start date: September 2026
End date: December 2026
Job Overview:
We are looking for co-op students pursuing chemical engineering or chemistry degrees interested in joining an exciting early-stage startup to scale the refinery of the future. This role will report to the Senior Scientist & Lab Manager and work closely with other members of the Hyfé team. The ideal candidate embodies our core values—unity, courage, dependability, momentum, and joy—values that are essential to tackling one of the greatest challenges of our time. This role reports to Hyfé’s Senior Scientist and Lab Manager working closely with the R&D Team.
Responsibilities
Collaborate with technical team to plan, prepare, and perform experiments.
Assist with pilot operations.
Follow all safety practices, including wearing proper PPE, completing safety trainings, and contributing to the ongoing development of safety systems and protocols.
Manage routine lab maintenance and upkeep, including inventory, cleaning, and organization.
Complete tasks within agreed timelines, tracking and communicating progress.
Maintain inventory of chemicals and supplies, and work with vendors as needed
Record, compile and analyze experimental data and present findings to the R&D team.
Assist with other areas of lab management as needed.
Perform duties in keeping with Hyfé’s values, policies and EHS protocols.
Requirements
Currently working on collegiate level chemical engineering or chemistry courses with laboratory component.
Capable of safely lifting and carrying laboratory materials and equipment weighing up to 40 lbs.
Ability to maintain a regular full-time schedule of 40 hours per week during standard business hours.
Innovative mindset with a can-do attitude and passion for Hyfé’s vision.
Strong interpersonal, communication, and time management skills.
Authorization to work in the US (unable to provide visa sponsorship for this position).
About Hyfé
See our coverage from the World Economic Forum here.
Every year, approximately one billion tons of nutrient-rich fruit and vegetable waste is discarded or under-utilized across global food systems. For processors, getting rid of this waste is costly and emissions-intensive, creating significant environmental impact with little to no economic return. Yet these waste streams contain valuable compounds that could transform the economics of businesses across the food system and help catalyze the production of sustainable chemicals and materials. Hyfé exists to change that.
Hyfé transforms food waste into high-value ingredients using a label-friendly, thermochemical refining process. Our products range from bioactives to fibers, and are being commercialized to make the food we eat healthier for people and the planet. Our team of scientists and engineers brings decades of expertise from the oil refining and chemical industries, specializing in scaling industrial processes and pioneering sustainable solutions.
At Hyfé, you’ll have the opportunity to build at the earliest stages of a mission-driven company—working alongside a world-class team, shaping real products, and helping define how the next generation of ingredients are made.
Our mission is simple: To transform carbon we waste into carbon we need.
____________________________________________________________________________
Hyfé is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability status, protected veteran status, or any other characteristic protected by law.
Posted on July 30, 2026
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Hyfé Foods · San Francisco, CA
Pay
Not listed
Setting
On-site
Hyfé
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Don't see the right role?
Part-time or Full-time
San Francisco, CA
We’ll be hiring individual contributor, management, and executive roles in the next few months.
Don’t see an open role that matches your background, but you’re passionate about Hyfé?
We’d still love to hear from you. Tell us a bit about yourself—we’re always looking for exceptional people!
San Francisco, CA - In-person, full time
About Hyfe:
See our coverage from the World Economic Forum here.
Every year, approximately one billion tons of nutrient-rich fruit and vegetable waste is discarded or under-utilized across global food systems. For processors, getting rid of this waste is costly and emissions-intensive, creating significant environmental impact with little to no economic return. Yet these waste streams contain valuable compounds that could transform the economics of businesses across the food system and help catalyze the production of sustainable chemicals and materials. Hyfé exists to change that.
Hyfé transforms food waste into high-value ingredients using a label-friendly, thermochemical refining process. Our products range from bioactives to fibers, and are being commercialized to make the food we eat healthier for people and the planet. Our team of scientists and engineers brings decades of expertise from the oil refining and chemical industries, specializing in scaling industrial processes and pioneering sustainable solutions.
At Hyfé, you’ll have the opportunity to build at the earliest stages of a mission-driven company—working alongside a world-class team, shaping real products, and helping define how the next generation of ingredients are made.
Our mission is simple: To transform carbon we waste into carbon we need.
Posted on July 8, 2026
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In one sentence, what type of role or opportunity would you be most interested in exploring at Hyfé?(required)
What excites you about joining a seed-stage company, and what do you know about Hyfé?(required)
Are you able to work in-person in San Francisco 5 days per week?(required)
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