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Director, Technical Accounting & External Financial Reporting Boston, MA Apply About Superluminal Medicines: Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation. Position Summary We are seeking an experienced and detail-oriented Director of Technical Accounting & External Financial Reporting to join our Finance team and help build scalable accounting and reporting capabilities for a growing preclinical-stage biotechnology company. This role will serve as a key finance leader responsible for technical accounting, external financial reporting, accounting policies, and financial reporting processes. The Director, Technical Accounting & External Financial Reporting will own the evaluation and documentation of complex accounting matters, lead external financial reporting activities, and partner closely with Finance leadership, external auditors, and cross-functional teams to ensure accurate and timely financial reporting. This individual will play a critical role in translating complex accounting guidance into practical business solutions while helping the organization develop strong financial infrastructure. The ideal candidate will be a collaborative accounting leader who combines strong technical accounting expertise with excellent communication skills. This individual will build strong relationships across the organization, partner effectively with business leaders, and serve as a trusted resource who helps teams understand the financial implications of business decisions while allowing them to focus on advancing the company’s mission. This is a highly visible role for an accounting leader who enjoys solving complex problems, building processes, and creating scalable reporting capabilities in a dynamic biotech environment. Who Would Love This Role? An accounting leader who enjoys operating at the intersection of technical accounting, business strategy, and operational execution. Someone who is energized by solving complex accounting challenges, building processes from the ground up, and helping a growing biotech company establish strong financial reporting capabilities. A natural relationship builder who enjoys partnering with scientists, business leaders, and cross-functional teams to understand the business, anticipate accounting considerations, and provide thoughtful guidance. Someone who sees Finance as a service organization and takes pride in being a trusted partner, translating complex accounting requirements into practical solutions while enabling teams across the company to focus on advancing the science. Key Responsibilities Technical Accounting & Accounting Policy Serve as the company’s technical accounting subject matter expert, providing guidance on complex accounting matters and transactions. Research, evaluate, and document accounting conclusions in accordance with U.S. GAAP. Prepare and maintain technical accounting memoranda, accounting position papers, and supporting documentation for significant accounting matters Evaluate accounting implications of complex transactions, including collaboration arrangements, revenue recognition, equity transactions, stock-based compensation, debt, financing arrangements, leases, and other strategic initiatives. Develop, maintain, and update accounting policies and procedures that promote consistent application of accounting guidance across the organization. Monitor emerging accounting standards and assess their impact on financial reporting and business operations. External Financial Reporting Lead preparation and review of quarterly and annual external financial reporting, including financial statements, footnote disclosures, supporting schedules, and related reporting packages Manage the financial reporting calendar and coordinate with cross-functional partners to ensure accurate and timely reporting. Support preparation of external reporting materials and financial disclosures. Develop processes and documentation to support efficient and scalable financial reporting. Partner with Finance leadership to enhance reporting processes, improve transparency, and support evolving business needs. Audit & Internal Controls Serve as a key point of contact for external auditors and manage audit activities related to technical accounting, financial reporting, and disclosures. Coordinate audit requests, prepare supporting documentation, and ensure timely resolution of audit questions. Support the design, implementation, and enhancement of internal controls and accounting processes. Identify opportunities to improve accounting operations, strengthen controls, and increase efficiency. Partner with Accounting and Finance team members to establish best practices and scalable processes. Cross-Functional Partnership & Process Development Serve as a trusted finance partner to business leaders by providing thoughtful accounting guidance and helping teams understand the financial implications of key decisions. Partner closely with Legal, Business Development, Operations, Research & Development, and Finance teams to evaluate accounting considerations related to business activities. Act as an educator and translator, simplifying complex accounting concepts and providing practical guidance to non-finance partners. Support the implementation and optimization of financial reporting tools, including reporting systems and disclosure management platforms. Develop strong relationships across the organization and contribute to a culture of collaboration, accountability, and continuous improvement. Minimum Qualifications Bachelor's degree in Accounting, Finance, or a related field, or equivalent combination of education and relevant professional experience. Active Certified Public Accountant (CPA) license. 5+ years of progressive technical accounting, external reporting, or financial reporting Experience working in a publicly traded company environment. Knowledge of U.S. Generally Accepted Accounting Principles (U.S. GAAP), including applying accounting guidance to complex business transactions. Experience preparing technical accounting analyses, accounting position papers, and financial statement disclosures. Experience serving as a primary contact or key liaison for external auditors during financial statement audits (e.g. Big Four) Ability to research accounting issues, evaluate alternatives, document conclusions, and communicate accounting positions to finance and non-finance stakeholders. Ability to prepare written analyses and communicate accounting concepts in a clear and understandable manner to senior management Ability to organize work, manage multiple priorities, and meet established deadlines in a changing business environment. Preferred Qualifications Experience in a clinical-stage biotech, pharmaceutical, or other life sciences organization. Experience with complex collaboration arrangements, revenue recognition, equity transactions, stock-based compensation, and financing transactions. Experience supporting financial reporting processes within a public company environment (e.g. SEC) Experience with Workiva, Active Disclosure, or similar financial reporting and disclosure management software. Experience implementing or enhancing accounting processes, controls, and reporting infrastructure. Familiarity with ERP systems (i.e. NetSuite) Experience supporting company growth, strategic transactions, or other complex business initiatives. Benefits: Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance. Equal Opportunity Statement: Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status. Get new jobs like this in your inbox We'll email you when Superluminal Medicines, Inc. posts a job like this one. Create alert Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country* Phone* Resume/CV* Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Will you require visa sponsorship now or in the future?* Select... Are you living in the Boston area or willing to relocate there?* Select... How did you hear about this opportunity?* Select... Do you hold an active CPA license?* Select... Do you have 5+ years of public company financial reporting experience? * Select... Do you have experience with SOX? * Select... Do you have experience managing external auditors and tax preparers? * Select... Submit application Powered by

Listed by Superluminal Medicines for a position based in the United States. Employers on this board attest they are hiring domestically.

Finance

98 days ago

Director, Financial Planning & Analysis (FP&A)

Superluminal Medicines · Boston, MA

Pay

$150k–240k

Setting

On-site

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Director, Financial Planning & Analysis (FP&A) Boston, MA Apply About Superluminal Medicines: Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation. Position Summary We are seeking an experienced and strategic Director of Financial Planning & Analysis (FP&A) to build and lead FP&A capabilities for a growing clinical-stage biotechnology company. This role will serve as a key finance partner to executive leadership and cross-functional teams, providing insights that support strategic decision-making, resource allocation, and long-term growth. The Director, FP&A will own financial planning, forecasting, business modeling, and performance analysis, with a focus on translating complex clinical development programs into actionable financial insights. This individual will partner closely with Research & Development, Clinical Operations, Corporate Operations, and Finance leadership to evaluate investment decisions, optimize resource allocation, and provide visibility into financial performance and future opportunities. The ideal candidate will be a collaborative business partner who builds strong relationships across the organization, particularly with scientific and clinical teams. This individual will help translate complex financial concepts into meaningful insights, allowing our scientists and operators to focus on advancing our programs while ensuring they have the financial visibility and support needed to make informed decisions. This is a highly visible role for a finance leader who enjoys building processes, developing scalable models, and partnering with scientific and operational leaders in a dynamic biotech environment. Who Would Love This Role? A finance leader who enjoys operating at the intersection of science, strategy, and finance. Someone who is energized by building processes from the ground up, partnering with senior leaders, and helping a growing biotech company make thoughtful decisions about where and how to invest resources. A natural relationship builder who enjoys working closely with scientists and operational teams, getting into the details of their programs, and helping translate complex financial concepts into meaningful insights. Someone who sees Finance as a service organization and takes pride in being a trusted business partner, enabling our scientific teams to focus on advancing science while providing the financial perspective needed to make thoughtful decisions. Key Responsibilities Strategic Financial Planning & Business Modeling Build and maintain comprehensive financial models incorporating clinical development timelines, program costs, operating assumptions, and strategic scenarios. Develop long-range financial plans and forecasts that support business objectives and capital allocation decisions. Analyze program-level investment requirements, clinical development costs, and resource needs across the pipeline. Develop scenario analyses to evaluate strategic alternatives, including clinical development strategies, partnership opportunities, and other business initiatives. Provide insights into cash runway, capital requirements, and financial trade-offs. Budgeting, Forecasting & Performance Management Lead the annual budgeting process and ongoing forecasting cycles, including quarterly updates and long-range planning. Partner with functional leaders across R&D, Clinical Operations, and Corporate Operations to develop realistic financial plans aligned with business priorities. Analyze actual results against budget and forecast, identifying trends, risks, opportunities, and recommended actions. Establish meaningful financial and operational metrics to measure business performance and support decision-making. Develop processes to improve financial visibility and accountability across the organization. Executive & Board-Level Reporting Prepare executive-level financial analyses, presentations, and insights for senior leadership and Board discussions. Translate complex financial, operational, and clinical information into clear recommendations for decision-makers. Support investor-facing analyses, diligence requests, and strategic financial materials. Develop reporting frameworks that highlight key business drivers, capital efficiency, and pipeline progress. Cross-Functional Partnership & Process Development Serve as a trusted finance partner to scientific and operational leaders by developing strong relationships, understanding their goals and challenges, and providing thoughtful financial guidance that enables teams to focus on advancing our science. Act as an educator and translator, simplifying financial concepts and removing administrative burdens while ensuring teams have the information needed to make effective business decisions. Partner with Accounting to ensure accurate financial reporting, forecasting inputs, and alignment between actual results and financial models. Develop scalable FP&A processes, tools, and reporting infrastructure to support company growth. Support implementation and optimization of financial systems and planning tools. Build program-level financial tracking methodologies to improve visibility into clinical development investments. Team Leadership & Development Build and develop FP&A capabilities as the organization grows. Mentor and coach finance team members in financial modeling, forecasting, and business partnership. Establish best practices for financial analysis, reporting, and strategic planning.] Minimum Qualifications Bachelor's degree in Accounting, Finance, Business Administration, or a related field, or equivalent combination of education and relevant professional experience. 10+ years of progressive FP&A, corporate finance, or strategic finance experience, preferably within biotechnology, pharmaceutical, or life sciences organizations. Experience building and maintaining complex financial models, including long-range planning, scenario analysis, and cash forecasting. Experience in biotech operating models, including preclinical and clinical development timelines, R&D investment drivers, and program-level financial planning. Experience preparing executive-level presentations and communicating complex financial concepts clearly. Experience with advanced Excel modeling skills and financial planning tools Experience identifying business drivers, trends, and opportunities. Preferred Qualifications Master's degree in Business Administration (MBA), Finance, Accounting, or a related field, or equivalent combination of education and relevant professional experience. Experience in a clinical-stage biotech or pharmaceutical company. Experience supporting company growth, financing activities, or strategic transactions. Experience implementing or enhancing FP&A systems (Adaptive Planning, Anaplan, NetSuite Planning & Budgeting, or similar). Familiarity with ERP systems such as NetSuite, Sage Intacct, or similar platforms. Experience developing Board-level financial materials. Experience with equity compensation modeling and workforce planning. Exposure to public company reporting requirements and SEC processes. Benefits: Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance. Equal Opportunity Statement: Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status. Get new jobs like this in your inbox We'll email you when Superluminal Medicines, Inc. posts a job like this one. Create alert Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country* Phone* Resume/CV* Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Will you require visa sponsorship now or in the future?* Select... Are you living in the Boston area or willing to relocate there?* Select... Have you provided support to a scientific organization as a finance business partner for 5+ years? * Select... Do you have expertise in creating financial models? * Select... Have you led or participated in an Annual Operating Plan with quarterly budget updates? * Select... How did you hear about this opportunity?* Select... Submit application Powered by

Listed by Superluminal Medicines for a position based in the United States. Employers on this board attest they are hiring domestically.

Science

99 days ago

Research Associate/ Senior Research Associate, Discovery Biology

Superluminal Medicines · Boston, MA

Pay

$75k–200k

Setting

On-site

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Research Associate/ Senior Research Associate, Discovery Biology Boston, MA Apply About Superluminal Medicines: Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation. About the Role: We are seeking a highly motivated Research Associate/Senior Research Associate with cell biology, assay development and screening experience to join our growing Biology team. The successful candidate is curious, self-driven and looking to expand their existing proficiencies in cell biology, assay development and screening to contribute to drug discovery programs. Key Responsibilities: Perform routine mammalian cell culture and maintain mammalian cell lines. Execute routine cell-based assays to support early-stage drug discovery programs. Under the guidance of the manager, assist with the development and optimization of new cell-based assays for screening. Generate, analyze, document, and upload experimental data to company databases in a timely and accurate manner. Ensure compliance with established laboratory practices, SOPs, and company policies, including both wet lab and electronic data management requirements. Minimum Qualifications: Bachelor's degree in Biology, Cell Biology, Biochemistry, or a related life sciences discipline. Minimum of 1 year of biotechnology or pharmaceutical industry experience Experience working with 384-well plate-based assay formats. Experience performing routine mammalian cell culture techniques. Experience with plate-based in vitro assays, including one or more of the following technologies: HTRF, luminescence, BRET, or Alpha assays. Experience executing cell-based assays, including assay optimization and routine screening campaigns. Basic understanding of early-stage drug discovery processes. Demonstrated ability to work effectively in a collaborative, cross-functional team environment. Preferred Qualifications: Experience with laboratory automation and/or semi-automated assay workflows Experience with cell-based assay development and optimization for high-throughput screening Experience in small molecule drug discovery Benefits: Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance. Equal Opportunity Statement: Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status. Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country* Phone* Resume/CV* Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Will you require visa sponsorship now or in the future?* Select... Are you living in the Boston area or willing to relocate there?* Select... How did you hear about this opportunity?* Select... Do you have at least one year of industry experience in biotech or pharma?* Select... Submit application Powered by

Listed by Superluminal Medicines for a position based in the United States. Employers on this board attest they are hiring domestically.

Human Resources

121 days ago

Senior Associate/ Manager, Payroll & Benefits

Superluminal Medicines · Boston, MA

Pay

$90k–200k

Setting

On-site

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Senior Associate/ Manager, Payroll & Benefits Boston, MA Apply About Superluminal Medicines: Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation. About the Role: We are seeking an experienced Senior Associate/ Manager Payroll & Benefits to join our team. In this role, you will own the end-to-end payroll cycle, administer comprehensive employee benefit programs, and serve as support for equity administration. You will support Finance, HR, and external advisors to ensure accuracy and full regulatory compliance. Who would love this job? A professional who is passionate about payroll and benefits administration and eager to expand their expertise in equity administration. A curious individual looking for an opportunity with a growing company and a small, cross-functional G&A team. Someone who is detail-oriented, process-driven, and a proactive problem solver with a customer-service mindset. An ambitious self-starter who enjoys working independently but also thrives as part of a collaborative and supportive team. Key Responsibilities: Payroll Administration Process multi-state, full-cycle payroll (semi-monthly) with accuracy and timeliness for all employees. Reconcile payroll registers, general ledger entries, and payroll-related balance sheet accounts. Ensure compliance with federal, state, and local wage and hour laws, tax regulations, and garnishment orders. Partner with accounting on payroll accruals, journal entries, month-end close activities, ad hoc reporting, and system integrations. Benefits Administration Administer health, dental, vision, life, disability, FSA/HSA, and 401(k) plans including onboarding, open enrollment, qualifying life events, and day-to-day employee inquiries. Coordinate with HR, benefits brokers, and carriers on plan changes, renewals, billing reconciliation, and claims escalations. Manage COBRA administration, ACA reporting (1094-C/1095-C), annual non-discrimination testing, as well as other reporting as assigned. Support leave of absence processes (FMLA, state leaves, personal leave). Develop, update, and communicate benefits and leave policies while serving as the primary resource for employee inquiries, issue resolution, and interpretation of plan and policy provisions. HR Administration & Employee Records Maintain accurate and up-to-date employee records in the HRIS, including new hires, terminations, transfers, promotions, compensation changes, and personal data updates. Process employment verifications, unemployment claims, and HR-related correspondence. Support HR compliance activities including I-9 administration, E-Verify, EEO-1, and applicable state HR filings. Respond to employee inquiries regarding HR policies, procedures, and programs; escalate complex issues appropriately. Support the administration of compensation change workflows, and merit increase processing in the HRIS. Onboarding & Offboarding Coordinate and facilitate the new hire onboarding record keeping, including pre-boarding paperwork, HRIS setup, benefits enrollment, and payroll activation. Administer offboarding processes including final pay calculations, benefits termination, equity notifications, equipment retrieval coordination, and exit interview scheduling. Maintain and continuously improve onboarding and offboarding checklists to reflect current policies, systems, and compliance requirements. Systems, Reporting & Process Improvement Serve as a functional administrator for the HRIS and payroll platform; manage configuration, integrations, and audits. Generate and analyze standard and ad-hoc compensation, benefits, and headcount reports for leadership and Finance. Identify and implement process improvements to increase efficiency, reduce error risk, and strengthen internal controls. Train managers and employees on self-service tools, equity portals, and benefits platforms. Equity Compensation Work with the current stock plan administrator to execute equity award programs, including ISOs/NQSOs. Maintain equity data integrity between the equity management platform and the HRIS/payroll system . Support equity expense calculations, JEs, and Black-Scholes inputs Calculate and withhold applicable taxes on equity events (vesting/exercises) and ensure accurate W-2 and supplemental income reporting. Qualifications: Education Bachelor’s degree in Accounting, Finance, Human Resources, Business Administration, or a related field; or equivalent professional experience. Preferred Experience 5+ years of progressive payroll and benefits administration experience, with at least 2 years in a publicly traded company environment. Demonstrated hands-on experience administering equity compensation plans (ISOs, NQSOs, and/or RSUs) and processing related payroll tax withholding and reporting. Direct involvement in proxy statement preparation or review. Working knowledge of SOX internal controls as they apply to payroll and HR data/processes. Certifications: CPP Certified Payroll Professional (APA) - Preferred and/or willing to attain CEP Certified Equity Professional - Preferred (desire to obtain preferred) Skills & Competencies: Technical Skills (required) Proficiency with a major payroll/HRIS platform, Paylocity a plus. Experience with an equity management platform, Carta is a plus. Advanced Microsoft Excel skills (pivot tables, VLOOKUP/XLOOKUP, data validation, etc). Familiarity with general ledger and ERP systems, NetSuite a plus. Excellent verbal and written communication skills Competencies & Attributes (required) Exceptional attention to detail and commitment to data accuracy in deadline-driven environments. Strong understanding of confidentiality obligations and discretion with sensitive employee and executive compensation data. Ability to communicate complex payroll, tax, and equity concepts clearly to non-technical stakeholders. Self-directed and organized, with the ability to manage multiple concurrent workstreams and deadlines. Collaborative partner for internal teams. Continuous improvement mindset, proactively identifies control gaps and proposes scalable solutions. Excellent customer service to support employees. Benefits: Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance. Equal Opportunity Statement: Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status. Get new jobs like this in your inbox We'll email you when Superluminal Medicines, Inc. posts a job like this one. Create alert Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country* Phone* Resume/CV* Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Will you require visa sponsorship now or in the future?* Select... Are you living in the Boston area or willing to relocate there?* Select... Are you willing to work on site at the Boston office 5 days per week?* Select... Do you have experience with stock compensation administration? If not, are you willing to learn this area?* Select... Do you have at least 2 years of progressive payroll and benefits administration experience in a publicly traded company environment?* Select... How did you hear about this opportunity?* Select... Submit application Powered by

Listed by Superluminal Medicines for a position based in the United States. Employers on this board attest they are hiring domestically.

Biotech/Pharma

145 days ago

Scientist-Principal Scientist, Protein Design & Structure

Superluminal Medicines · Boston, MA

Pay

Not listed

Setting

On-site

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Scientist-Principal Scientist, Protein Design & Structure Boston, MA Apply About Superluminal Medicines: Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation. Position Summary We are seeking a highly innovative and experienced Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering and production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs. This role involves hands-on laboratory work and scientific leadership. Key Responsibilities Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression. Expression & Purification: Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM). Cross-Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization. Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies. Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings. Required Qualifications Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience; or a master’s or bachelor’s degree in a related field with commensurate industry experience. Deep knowledge of GPCR biology and membrane protein structure-function relationships. Proven expertise in molecular biology (cloning, construct design, mutagenesis). Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC). Familiarity with protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis). Excellent communication, interpersonal, and leadership skills. Preferred Qualifications Experience with structural biology methods (data collection and processing for Cryo-EM). Experience in laboratory automation in protein sciences & purification. Background in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction). Benefits: Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance. Equal Opportunity Statement: Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status. Create a Job Alert Interested in building your career at Superluminal Medicines, Inc.? Get future opportunities sent straight to your email. Create alert Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country* Phone* Resume/CV* Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Will you require visa sponsorship now or in the future?* Select... Are you living in the Boston area or willing to relocate there?* Select... How did you hear about this opportunity?* Select... Submit application Powered by

Listed by Superluminal Medicines for a position based in the United States. Employers on this board attest they are hiring domestically.

Science

157 days ago

Senior Scientist - Principal Scientist, Computational Chemistry

Superluminal Medicines · Boston, MA

Pay

$120k–200k

Setting

On-site

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Senior Scientist - Principal Scientist, Computational Chemistry Boston, MA Apply About Superluminal Medicines: Superluminal Medicines is a generative biology and chemistry company revolutionizing the speed and accuracy of how small molecule medicines are created. The Company’s platform aims to create candidate-ready compounds with unprecedented speed using a combination of deep biology, computational and medicinal chemistry, machine learning, and proprietary big data infrastructure. We are expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation. About the Role: We are seeking a high-impact Computational Chemist to join our integrated discovery team. In this role, you will be the computational engine of our programs, combining physics-based modeling, machine learning and structural biology to generate the quantitative predictions and develop necessary workflows to drive small molecule drug discovery. You will serve as a core strategic partner to medicinal chemists and biologists, focusing on compound design and tool development to impact discovery pipeline and address unmet computational needs. Key Responsibilities: Integrate physics-based simulations with ML predictions to achieve the quantitative accuracy required to prioritize compounds for synthesis Collaborate with a team of interdisciplinary scientists to develop actionable hypotheses and design computational experiments Design and prioritize chemical matter specifically aimed at hitting key program milestones, such as establishing in vivo POC, achieving selectivity windows, or optimizing ADMET profiles for candidate selection Develop, validate and deploy computational workflows to optimize the "Design-Make-Test-Analyze" cycles and address gaps Required Qualifications: Ph.D. in Computational Chemistry, Biophysics, or a related field 1-3+ years of experience in a biotech or pharma setting performing computational support for small molecule drug discovery Advanced knowledge of physics-based and ML computational chemistry packages including knowing when and how to deploy various tools for maximum project impact Exceptional ability to communicate the "why" behind a design to a diverse scientific audience Design experience working in concert with medicinal chemistry teams to design synthesizable compounds that efficiently work towards defined goals of activity, affinity, selectivity, properties, etc A proven track record for innovation in structure-based small molecule drug discovery including developing and validating new workflows and techniques or expansions of existing ones Preferred Qualifications: Experience working with structural biology teams to extract the most information possible from cryo-EM and x-ray crystallography experiments and using this to accelerate programs using structure-based drug discovery techniques Proven experience using ML to scale physics-based insights, specifically in the context of large-scale virtual screening or FEP-guided lead optimization A proven track record for innovation in structure-based small molecule drug discovery including developing and validating new workflows and techniques or expansions of existing ones Skills & Competencies: Expert level use of structure-based small molecule drug discovery software tools including protein preparation, docking, FEP, QM, conformer selection. (Schrodinger suite, OpenEye, MOE, etc) Ability to work directly in a Linux-based environment Familiarity with cloud computing infrastructure (AWS, GCS) is a plus Python scripting and prototyping experience including knowledge of key packages (RDKit, scikit-learn, numpy, pandas, pytorch, etc) Benefits: Superluminal offers a comprehensive benefits package that fully covers employees’ annual deductibles and monthly premiums for medical, dental, and vision insurance. The package also includes a 401(k) match program, a Massachusetts transportation subsidy, equity, unlimited paid time off, and both disability and life insurance. Equal Opportunity Statement: Superluminal Medicines is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status. Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country* Phone* Resume/CV* Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Will you require visa sponsorship now or in the future?* Select... Are you living in the Boston area or willing to relocate there?* Select... How did you hear about this opportunity?* Select... Do you have 1-3+ years of experience in a biotech or pharma setting performing computational support for small molecule drug discovery?* Select... Do you have a Ph.D. in Computational Chemistry, Biophysics, or a related field, or Master’s with relevant industry experience?* Select... Submit application Powered by

Listed by Superluminal Medicines for a position based in the United States. Employers on this board attest they are hiring domestically.

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