Scientist II/Sr. Scientist I, Chemical Biology (Must Have Intact Mass Spectrometry Experience)

Antares Therapeutics · Boston, MA

Pay

$145k–185k

Setting

On-site

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Back to jobs Scientist II/Sr. Scientist I, Chemical Biology Boston, MA Apply Salary Band: $145,000-$185,000 Location: Boston, MA Job Summary Antares Therapeutics is seeking a motivated and detail-oriented Scientist II/ Sr Scientist I to join our Chemical Biology team. As a member of the team, you will be responsible for designing and executing proteomic screens to identify and validate novel therapeutic targets, elucidate mechanisms of inhibition, and enable biophysical small-molecule characterization through cycles of hit identification and SAR advancement. Achieving these objectives will involve the application of innovative chemoproteomic methodologies and the utilization of advanced HPLC and mass spectroscopy (MS) instrumentation. This position offers a unique opportunity to work in a collaborative, fast-paced environment at the intersection of chemistry and biology. Key Responsibilities Serve as the chemical biology functional lead on programs, reporting and presenting discovery evidence for multiple small-molecule programs Design and execution of MS-based chemical biology experiments supporting target hit finding, compound profile optimization, and mechanism-of-action studies Analyze experimental data, interpret results, and present findings at internal meetings. Maintain accurate and detailed laboratory records as well as up-to-date electronic notebooks Design and execute quantitative proteomics experiments using data-independent acquisition (DIA) or targeted workflows Contribute to the development of new proteomic workflows and the evaluation of emerging chemical biology strategies Help maintain Orbitrap-based mass spectrometer and HPLC instrumentation Professional Experience/Qualifications PhD. in Chemical Biology, Analytical Chemistry, Biochemistry, Proteomics, or a related discipline with 2–6 years of relevant industry and/or postdoctoral experience Proficiency in operating and maintaining mass spectrometry and liquid chromatography instrumentation is required Previous experience with MS-based proteomic methods to study protein/peptide modification, protein turnover, and/or targets using enrichment methods is required Experience in small molecule drug mechanisms of action (e.g., covalent ligands, molecular glues, PROTACs, etc.) is desirable Knowledge/experience with activity-based protein profiling (ABPP) is desirable Familiarity with Proteome Discoverer, Skyline, DIA-NN, Spectronaut, MaxQuant, or related proteomics software is desirable Programming experience and data analysis (g., Python or R) for statistical analysis, visualization, and interpretation of large biological datasets is desirable Ability to perform routine laboratory tasks requiring manual dexterity, including pipetting, sample preparation, and operation of analytical instrumentation The anticipated annual salary range for this position is $145,000-$185,000 annually. The actual salary offered will be based on a number of factors, including but not limited to the qualifications of the applicant, years of relevant experience, level of education attained, certifications or other professional licenses held, and if applicable, the location in which the applicant lives and/or from which they will be performing the job. Create a Job Alert Interested in building your career at Antares Therapeutics ? Get future opportunities sent straight to your email. Create alert Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country Phone Resume/CV Attach Attach Dropbox Google Drive Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Dropbox Google Drive Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf LinkedIn Profile Website Do you currently reside the in the Greater Boston Area? * Select... If you do not currently reside in the Greater Boston Area, are you open to relocation for this opportunity? Select... Will you now or in the future require sponsorship?* Select... What are your base salary compensation expectations? * Provide a specific example in your previous proteomics research experience where the detection/identification of a peptide/protein target(s) proved to be challenging. Explain how you identified the issue, what sample preparation and LC and/or MS approaches were taken to address the problem, how findings were used to enable reproducible LC-MS data collection, and what impact this made on the research.* Antares research programs focus on covalent drug discovery. Describe specific research experiences that you have with detecting and quantifying covalent protein modification. What chemical biology and/or proteomics approaches have you employed to identify, characterize, and evaluate protein modification on cell biological behavior in these cases? What problems have you had to solve? How did your findings impact the understanding of the target’s function and regulation in normal biology or a disease state in the cases that you describe?* Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file. As set forth in Antares Therapeutics ’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law. Gender Select... Are you Hispanic/Latino? Select... Race & Ethnicity Definitions If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. 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The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp. How do you know if you have a disability? A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to: Alcohol or other substance use disorder (not currently using drugs illegally) Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS Blind or low vision Cancer (past or present) Cardiovascular or heart disease Celiac disease Cerebral palsy Deaf or serious difficulty hearing Diabetes Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders Epilepsy or other seizure disorder Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome Intellectual or developmental disability Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD Missing limbs or partially missing limbs Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS) Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities Partial or complete paralysis (any cause) Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema Short stature (dwarfism) Traumatic brain injury Disability Status Select... 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