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Computational Biologist
Freenome · Remote
Pay
Not listed
Setting
Remote
Listed by Freenome for a position based in the United States. Employers on this board attest they are hiring domestically.
Staff Computational Biologist
Freenome · Remote
Pay
Not listed
Setting
Remote
Staff Computational Biologist
Remote
Apply
About this opportunity:
At Freenome, we are seeking a Staff Computational Biologist to help grow the Freenome Computational Biology, Assay Research (CBAR) team. As part of our team, you will apply your scientific expertise to the development of early, noninvasive tests for cancer detection. With a strong background in NGS assay development, bioinformatics, statistics, and molecular biology, you will design and execute research studies to drive early research of prototype cancer early detection products using cfDNA as biomarker. You will work closely and cross-functionally with many teams, including Molecular Research and Development, Model R&D, and Computational Biology, Assay Development to enable the concept and feasibility of multiple molecular assays as part of Freenome’s diagnostic products.
The role reports to a Manager and Senior Staff Computational Biologist. This position can be a hybrid or fully remote role.
What you’ll do:
Lead the analysis and interpretation of molecular and clinical data in the context of early cancer detection, serving as a key thought leader on the Computational Science team.
Suggest research hypotheses and areas for potential computational model and assay improvement; then plan, scope, and execute associated research in partnership with a multidisciplinary team, owning projects from ideation through implementation.
Develop bioinformatics pipelines to enable high throughput NGS data processing and analysis.
In collaboration with wet lab scientists, rapidly characterize and iterate on experimental methods by providing real-time assessments of assay performance, quality control, and clinical/diagnostic utility.
Remain at the forefront of molecular techniques in oncology, and collaborate with the larger team to bring forward the next generation of assays for early cancer detection.
Must haves:
PhD degree in computational biology, cancer biology, statistics, bioinformatics, or related quantitative field.
6+ years of scientific industry experience applying computational techniques for biological discovery and product development, ideally to cancer or diagnostics applications in industry.
Extensive experience in NGS assay and pipeline development. Demonstrated track record of implementing complex workflows for high throughput NGS data processing.
Strong quantitative reasoning and data analysis skills, with a demonstrated ability to apply them effectively to relevant scientific problems.
Strong computational and programming skills, including thorough experience with Python statistical packages (Numpy, Matplotlib, Pandas) or equivalents in other languages like R.
Excellent oral and written communication skills to communicate to both scientific and broader audiences.
Ability to work on a cross-functional team in our highly collaborative environment, working with both computational and experimental scientists.
Nice to haves:
Expert knowledge of chromatin biology, liquid biopsy, DNA methylation and their relevance in cancer early detection.
Extensive experience working with DNA methylation data for biomarker discovery research.
Experience in developing, applying, and evaluating statistical and/or machine learning algorithms.
Benefits and additional information:
The US target range of our base salary rate for new hires is $188,275 - $270,375. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.
Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Applicants have rights under Federal Employment Laws.
Family & Medical Leave Act (FMLA)
Equal Employment Opportunity (EEO)
Employee Polygraph Protection Act (EPPA)
California applicants please review the CCPA Notice at Collection here:
California Consumer Privacy Act (CCPA)
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Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.
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Research Scientist I/II
Freenome · Brisbane, California
Pay
$132k–167k
Setting
On-site
Research Scientist I/II
Brisbane, California
Apply
About this opportunity:
At Freenome, you will help develop the assay technologies used to analyze patient samples and contribute to our mission of early detection and intervention in human disease. As a Research Scientist I/II, you will provide experience in next-generation-sequencing (NGS)-based analyses of DNA. As a Research Scientist in Genomics, you will contribute to the program’s technical base by creating and optimizing new next-generation sequencing (NGS) assays and workflows for DNA/RNA, or to the program’s scientific base by elevating our understanding of the biological context of these assay signals in cancer. In this role, you will perform studies to evaluate emergent technologies that have the potential to improve our diagnostic tests, and collect and analyze NGS datasets (including genomics, epigenomics, and transcriptomics) for biomarker discovery. You will also work closely with computational biologists and machine learning scientists to provide biological and technical insights, and to provide new data sources to enhance ongoing computational research projects.
The role reports to a Manager of Molecular Research. This role will be an Onsite role.
What you’ll do:
Independently design and execute experiments to help optimize the performance of Freenome’s new or existing assays.
Prototype new next-generation sequencing (NGS) methods, optimize the performance of existing assays, and execute biomarker discovery studies on clinical samples.
Assist with project planning and timeline generation and work with cross-functional teams to coordinate tasks within and across projects.
Take detailed notes, gather high-quality data, and openly communicate on lessons learned while performing experiments.
Independently troubleshoot workflows and understand the rationale behind workflow optimization choices.
Help with process improvements across the lab by thinking critically about the execution of all experiments.
Perform advanced analysis and data visualization of results to answer experimental questions and guide next steps.
Prepare and present experiment or project results at internal meetings, with clear articulation of goals, results, conclusions, and how results presented fit in to broader project.
Must haves:
PhD in molecular biology, biochemistry, genetics, or a related field or Bachelor’s or Master’s with 8+ years experience post-Bachelor’s in the life sciences (industry and/or academia).
Hands-on experience with and expert-level knowledge in NGS based workflows including sample preparation, library preparation, target capture, and sequencing.
Biological understanding of human cell-free nucleic acids, single-cell analysis methods, immunology, and/or cancer biology.
Ability to perform advanced data analysis and critically examine experimental results.
Proven track record of designing and running successful experiments, preparing data for review, and giving effective scientific presentations.
Clear and proactive communication skills and ability to collaborate effectively with team members in the same and adjacent disciplines.
Flexible and highly motivated to learn new skills and comfortable adapting to changing priorities.
Nice to haves:
Ability to perform bioinformatic analysis in a scientific programming language (e.g., Python or R).
Experience handling and preparing blood and/or tissue samples.
Experience running high-throughput experimental designs and/or assays on an automated liquid handling platform.
Experience using ELN (electronic lab notebook) and LIMS (lab information management system).
Benefits and additional information:
The US target range of our base salary rate for new hires is $132,050 - $167,475. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.
Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Applicants have rights under Federal Employment Laws.
Family & Medical Leave Act (FMLA)
Equal Employment Opportunity (EEO)
Employee Polygraph Protection Act (EPPA)
California applicants please review the CCPA Notice at Collection here:
California Consumer Privacy Act (CCPA)
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Freenome’s mission relies heavily on optimizing and innovating next-generation sequencing (NGS) assays. Can you describe a specific instance where you independently designed an experiment to troubleshoot or optimize a complex NGS workflow (e.g., sample preparation, library preparation, or target capture)? What challenges did you face, and how did you critically evaluate the data to guide your next steps?*
In this role, you will work closely with computational biologists and machine learning scientists to provide biological insights for biomarker discovery. Tell us about a time you collaborated with computational teams or stakeholders in adjacent disciplines on a genomics dataset. How did you communicate your biological findings to guide the project? (Note: If you have experience using Python or R for your own bioinformatic analysis, please highlight how you utilized it in this project).*
A key aspect of this role is evaluating emergent technologies and understanding the biological context of assay signals in cancer. Briefly describe your hands-on expertise with human cell-free nucleic acids, single-cell analysis methods, immunology, and/or cancer biology. How have you previously prototyped a new method or evaluated an emerging technology to improve biological detection or answer a challenging scientific question?*
Are you legally authorized to work in the United States?*
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Will you now or in the future require sponsorship for an employment visa status (e.g., H-1B, TN, O-1, etc.) to work for our company?*
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Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.
As set forth in Freenome’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
Gender
Select...
Are you Hispanic/Latino?
Select...
Race & Ethnicity Definitions
If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:
A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.
A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.
An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.
An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.
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Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.
Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.
How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:
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Listed by Freenome for a position based in the United States. Employers on this board attest they are hiring domestically.
Staff Computational Biologist
Freenome · Remote
Pay
Not listed
Setting
Remote
Staff Computational Biologist
Remote
Apply
About this opportunity:
At Freenome, we are seeking a seasoned Staff Computational Biologist to help grow the Freenome Computational Science team. The ideal candidate is an expert in computational biology, genomics, and modeling, with a proven track record in industry settings. In this role, you will apply your background in computational biology and statistics to drive the creation of new applications and enhance algorithms for identifying molecular signatures of cancer. You will collaborate closely with machine learning scientists and computational biologists to iteratively advance computational models and assays, playing a key role in bringing products to the clinic. By joining us, you will have a significant impact on the continued growth of an organization dedicated to changing the entire landscape of cancer.
The role reports to the Manager and Staff Computational Biologist leading genomics modeling within Computational Science. This position can be onsite, hybrid, or remote (US only), based out of our campus in Brisbane, California.
What you’ll do:
Serve as a key thought-leader on the Computational Science team, leading the analysis and interpretation of cancer's molecular signatures and staying current with the field.
Guide and contribute to the development of models that characterize biological changes associated with cancer.
Execute rigorous computational analyses on data from best-in-class molecular assays, including whole genome sequencing, whole genome bisulfite sequencing, targeted sequencing, RNA sequencing, and protein quantitation.
Design novel statistical models for the evaluation, characterization, and modeling of these data types within the context of cancer biology and progression.
Identify research hypotheses and potential areas for model improvement; plan, scope, and execute associated research projects with a skilled team of computational biologists.
Solve complex analytical challenges inherent to the study of cell-free circulating nucleic acids and proteins.
Partner closely with molecular biologists to collaboratively refine wet lab experiments, and with development scientists to turn research models into products.
Support the professional development and career growth of talented, cross-functional computational biologists within your team.
Must haves:
PhD or equivalent experience in a relevant quantitative field (e.g., computational biology, cancer biology, statistics, bioinformatics).
At least 8 years of post-PhD experience applying computational techniques for biological discovery and product development, preferably in cancer or diagnostics within an industry setting.
Deep expertise in cancer and molecular biology, with a proven ability to leverage this knowledge for computational biology and diagnostics problems in cancer.
Extensive experience analyzing data and developing models for high-throughput, quantitative technologies in genomics, epigenomics, transcriptomics, proteomics, (e.g., Methyl-seq, ATAC-seq, RNA-seq, Hi-C, immunodetection assays).
Proficiency in computational and programming skills, including extensive experience with Python statistical packages (Numpy, Matplotlib, Pandas) and modeling packages (Scikit-learn, TensorFlow, PyTorch) or equivalents in languages like R or C/C++.
Nice to haves:
Experience training, evaluating, or applying biological sequence models—specifically sequence-to-function models that learn and predict functional biology directly from raw DNA, RNA, or protein sequences.
Experience developing or applying single-cell genomic or transcriptomic models to translate biological heterogeneity into generalizable regulatory or epigenomic signatures.
Experience modeling cell-free DNA (cfDNA) signals specifically for early disease detection and diagnostic applications.
Benefits and additional information:
The US target range of our base salary rate for new hires is $188,275 - $270,375. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.
Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Applicants have rights under Federal Employment Laws.
Family & Medical Leave Act (FMLA)
Equal Employment Opportunity (EEO)
Employee Polygraph Protection Act (EPPA)
California applicants please review the CCPA Notice at Collection here:
California Consumer Privacy Act (CCPA)
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Do you have experience with building models for NGS data?*
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At least 8 years of post-PhD experience applying computational techniques for biological discovery and product development?*
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Are you proficient with Python statistical packages (Numpy, Matplotlib, Pandas) and modeling packages (Scikit-learn, TensorFlow, PyTorch)?*
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Are you legally authorized to work in the United States?*
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Will you now or in the future require sponsorship for an employment visa status (e.g., H-1B, TN, O-1, etc.) to work for our company?*
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Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.
As set forth in Freenome’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
Gender
Select...
Are you Hispanic/Latino?
Select...
Race & Ethnicity Definitions
If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:
A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.
A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.
An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.
An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.
Veteran Status
Select...
Voluntary Self-Identification of Disability
Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 07/31/2029
Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.
Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.
How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:
Alcohol or other substance use disorder (not currently using drugs illegally)
Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
Blind or low vision
Cancer (past or present)
Cardiovascular or heart disease
Celiac disease
Cerebral palsy
Deaf or serious difficulty hearing
Diabetes
Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
Epilepsy or other seizure disorder
Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
Intellectual or developmental disability
Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
Missing limbs or partially missing limbs
Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
Partial or complete paralysis (any cause)
Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
Short stature (dwarfism)
Traumatic brain injury
Disability Status
Select...
PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.
Submit application
Powered by
Listed by Freenome for a position based in the United States. Employers on this board attest they are hiring domestically.
Staff Biostatistician
Freenome · Remote
Pay
Not listed
Setting
Remote
Staff Biostatistician
Remote
Apply
About this opportunity:
We are seeking a Staff Biostatistician to expand the Freenome Biostatistics team. This role will support statistical study design, analysis, summarization of clinical studies to support research, development and regulatory submissions for Freenome’s in vitro diagnostic products (IVDs). The ideal candidate is passionate about biostatistics and the opportunity to have a significant impact to change the landscape of early cancer detection.
This role will report to the Senior Director, Biostatistics. This role will be a Remote role.
What you’ll do:
Perform in a lead Biostatistician role and provide technical expertise as a core team member of high complexity clinical studies, including statistical oversight and attending relevant project meetings.
Provide expert level statistical guidance and thought leadership for innovative study design and clinical development plans, including endpoint selection powering.
Develop the statistical sections of the study protocol for clinical studies.
Responsible for interpreting analysis results and ensuring reporting accuracy in study reports and regulatory documents.
Conduct overall statistical review of TFLs for clinical studies.
Manage operations work with internal statistical programmers to ensure timeliness and quality of deliverables.
Represent Biostatistics in interactions with regulatory authorities (e.g FDA) and during audits.
Support the preparation of abstracts, oral presentations, manuscripts and written reports by ensuring the results of clinical programs and studies are effectively communicated to internal and external stakeholders.
Provide statistical expertise to internal and external stakeholders (e.g., presentation/publication, Marketing, Health Economics & Reimbursement).
Create, maintain, and implement SOPs, processes, standards, and work instructions with respect to biostatistics to ensure compliance, accuracy, efficiency, and optimization.
Must haves:
Masters degree or higher in Statistics, Biostatistics or Math.
10+ years of lead project work as a statistician on clinical trial projects.
Expert understanding of related aspects of biostatistics processes and systems.
Excellent written and verbal communication skills including the ability to interact professionally with all organizational levels to drive achievement of deliverables.
Strong interpersonal and relationship management skills including the ability to proactively elevate and resolve issues cross-functional to ensure project objectives are met.
Comprehensive organizational, judgment, analytical, decision-making, and influencing skills.
Proven successful project management leadership skills.
Expert understanding of clinical trial design while identifying applications of functional knowledge and methodologies to resolve complex problems.
Experience leading briefings and technical meetings for internal and external stakeholders.
Ability to develop effective peer, cross functional and cross business relationships to maximize best practice sharing and team effectiveness.
Ability to thrive in a fast paced, dynamic, and constantly changing work environment.
Strong programming skills using R (required) and Python (preferred). Demonstrated proficiency with literate programming (R markdown/ Sweave).
Nice to haves:
Ph.D degree or higher in Statistics, Biostatistics or Math.
Experience leading IVD clinical Biostatistics to FDA submission.
Knowledge of CDISC requirements preferred.
Benefits and additional information:
The US target range of our base salary rate for new hires is $166,175 - $237,825. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.
Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
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