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Scientist II, Display Technologies
South San Francisco, California, United States
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About Xaira Therapeutics
Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.
About the Role
We are looking for an accomplished protein biochemist to own phage display campaigns end-to-end within our Display Technologies group. You bring deep hands-on display expertise and the judgment to design selection strategies, troubleshoot challenging targets, and turn campaigns into high-quality datasets that feed AI antibody design. You take pride in rigorous bench execution, you think critically about experimental design, and you are comfortable working against difficult target classes—including membrane proteins presented in cell-based expression systems or recombinant formats.
Beyond your own bench work, you will help raise the level of the group: mentoring associate scientists, setting technical standards, and partnering with computational and engineering colleagues to scale data generation. You thrive in a fast-paced, collaborative environment where pushing the boundaries of what is possible is the norm.
Responsibilities
Independently design, execute, and own phage display campaigns from library through panning and hit validation, across both soluble antigens and membrane-protein targets (e.g., GPCRs) presented in cell-based expression systems or recombinant formats.
Develop and optimize selection strategies for difficult target classes, including troubleshooting antigen production, presentation, and quality control.
Design and build display libraries, applying strong molecular biology fundamentals (cloning, mutagenesis, assembly) to generate high-quality, diverse repertoires.
Design and run clonal-level affinity and functional characterization—including flow cytometry (FACS), ELISA, and SPR—and help adapt these assays to higher-throughput and automated formats.
Partner with computational and ML colleagues to generate, structure, and quality-control data at scale for model training and evaluation.
Mentor associate scientists on display workflows, experimental design, and lab best practices; contribute to technical standards within the group.
Contribute to and lead the preparation of technical reports, presentations, and documentation of methods and results.
Qualifications
PhD in Molecular Biology, Biochemistry, Immunology, Protein Engineering, or a related field, with 2–4 years of relevant industry experience.
Significant hands-on expertise with antibody/protein discovery by phage display, including library design, build, panning/selection, and hit validation.
Strong molecular biology skills for library construction, including cloning, mutagenesis, and assembly, with the rigor to build high-quality, diverse libraries.
Hands-on flow cytometry (FACS) experience is required, including data interpretation and gating strategy.
Demonstrated ability to run campaigns independently and troubleshoot challenging targets; experience with membrane proteins (e.g., GPCRs) in cell-based expression systems or recombinant formats is strongly preferred.
Strong working knowledge of antibody binding and characterization assays (e.g., ELISA) and proficiency in core molecular and cell biology techniques, including mammalian cell culture.
Excellent analytical and problem-solving skills, with meticulous attention to detail and a rigorous, organized approach to experimental design and documentation.
Strong written and verbal communication skills, with the ability to present complex scientific concepts to both technical and non-technical audiences.
Ability to work effectively in a collaborative, multidisciplinary team, with a track record of fostering knowledge-sharing and supporting more junior colleagues.
Nice to Have
Experience with label-free affinity characterization (SPR, BLI/Octet).
Experience with alternative display formats (yeast, mammalian, or ribosome/mRNA display).
Experience with lab automation (e.g., Hamilton, Tecan, or similar liquid handling).
Working knowledge of scripting for analysis of large datasets (e.g., Python or R).
Compensation
Annual
We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $124,000 to $155,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.
Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.
TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.
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For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.
As set forth in Xaira Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
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A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.
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An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.
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Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.
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Science
48 days ago
Scientist II, Genomic Core
Xaira Therapeutics · South San Francisco, California, United States
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Scientist II, Genomic Core
South San Francisco, California, United States
Apply
About Xaira Therapeutics
Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.
About the Role
As a Scientist II on Xaira's Genomics Core team within the High Throughput Biology organization, you will play a key role in generating high-quality sequencing data that powers our discovery platform and AI-driven research. You will serve as a technical leader responsible for designing, developing, optimizing, and executing next-generation sequencing (NGS) workflows, with a primary focus on Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq. You will partner closely with Functional Genomics, Disease Biology, Automation, and Computational Biology teams to develop scalable sequencing strategies that support CRISPR-based perturbation studies, single-cell genomics, and other high-throughput discovery efforts.
The ideal candidate is an experienced experimental scientist with deep expertise in NGS library preparation, Illumina sequencing operations, and 10x Genomics workflows. This is a highly collaborative, hands-on laboratory role that requires independent scientific thinking, experimental design, and technical leadership to implement new technologies and continuously improve genomics workflows across the organization.
Responsibilities
Perform high-quality next-generation sequencing operations across Illumina platforms, including MiSeq, NextSeq, and NovaSeq.
Independently design, develop, optimize, validate, and troubleshoot sequencing workflows to improve data quality, throughput, scalability, and reproducibility.
Prepare and QC sequencing libraries for a variety of applications, including 10x Genomics single-cell RNA sequencing, bulk RNA sequencing, CRISPR-based sequencing assays, and targeted sequencing workflows.
Design sequencing strategies and provide technical guidance to cross-functional project teams to ensure generation of high-quality datasets that address biological and computational objectives.
Partner with Functional Genomics scientists to support Perturb-seq, pooled CRISPR screening, guide sequencing, and other genomics-based discovery programs.
Collaborate with Automation Engineers to develop, implement, and scale automated library preparation and sequencing workflows.
Work closely with Computational Biology teams to ensure sequencing data meets quality standards for downstream analysis and AI/ML applications.
Serve as a technical subject matter expert for sequencing technologies by evaluating new methodologies, identifying experimental risks, troubleshooting complex technical challenges, and recommending scientifically sound solutions.
Perform routine maintenance, calibration, and troubleshooting of sequencing instrumentation and associated laboratory equipment.
Manage sequencing sample intake, experimental tracking, reagent inventory, and laboratory documentation.
Maintain accurate experimental records using electronic laboratory notebooks (ELN) and laboratory information management systems (LIMS).
Evaluate and implement emerging sequencing technologies, library preparation methods, and genomics workflows to expand core capabilities.
Present technical updates, experimental findings, and workflow improvements to cross-functional project teams.
Contribute to laboratory operations while ensuring compliance with safety and quality standards.
Qualifications
Ph.D. in Functional Genomics, Molecular Biology, Genetics, Genomics, or a related discipline with 2+ years of industry experience, or M.S./B.S. with equivalent industry experience.
Extensive hands-on experience operating Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq.
Extensive hands-on experience with 10x Genomics workflows: 3’, 5’, ATAC, Multiome, Flex, etc.
Strong expertise in next-generation sequencing library preparation, including single-cell RNA-seq, bulk RNA-seq, CRISPR-based sequencing assays, and targeted sequencing workflows.
Demonstrated experience supporting CRISPR-based genomics workflows, including Perturb-seq, pooled CRISPR screens, guide sequencing, or related functional genomics applications.
Demonstrated ability to independently design, optimize, troubleshoot, and execute complex genomics experiments with minimal supervision.
Proven experience developing, validating, and implementing new NGS workflows while driving improvements in data quality, throughput, and reproducibility.
Strong understanding of sequencing quality control methods, library characterization techniques, and experimental troubleshooting.
Experience collaborating with multidisciplinary teams, including molecular biologists, automation engineers, and computational scientists.
Ability to independently prioritize multiple projects while providing scientific and technical leadership within cross-functional teams.
Excellent written and verbal communication skills, including the ability to present technical findings to diverse scientific audiences.
A proactive, collaborative mindset with strong troubleshooting and problem-solving abilities.
Enthusiasm for working in a highly interdisciplinary startup environment.
Preferred Qualifications
Experience working in a genomics core facility or high-throughput sequencing laboratory.
Experience developing or supporting automated library preparation workflows.
Experience with additional 10x Genomics applications such as ATAC, Immune Profiling, Multiome, etc.
Experience with molecular cloning, cell engineering, lentiviral workflows, or other functional genomics techniques.
Basic familiarity with bioinformatics tools, NGS data quality assessment, and sequencing data analysis pipelines.
Experience evaluating and implementing emerging sequencing technologies.
Experience supporting AI/ML-driven biological research through generation of high-quality genomic datasets.
Compensation
Annual
We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. We offer a competitive package that includes base salary, bonus, and equity. The base pay range for this position is expected to be $124,000 to $155,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.
Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.
TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. Xaira Therapeutics is not responsible for any fees related to unsolicited resumes.
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This role is based in our South San Francisco office and requires five days per week in-office. How does this align with your preferences?*
Describe your experience designing and executing NGS workflows and working with Illumina sequencing platforms:*
Describe your experience supporting CRISPR-based perturbation workflows (scrna-seq, perturb-seq, Bulk RNA-seq)*
What excites you about the opportunity to work at Xaira?*
Please describe your experience managing or mentoring junior research associates:*
Voluntary Self-Identification
For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.
As set forth in Xaira Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.
Gender
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Are you Hispanic/Latino?
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Race & Ethnicity Definitions
If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:
A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.
A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.
An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.
An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.
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OMB Control Number 1250-0005
Expires 07/31/2029
Why are you being asked to complete this form?
We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.
Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.
How do you know if you have a disability?
A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:
Alcohol or other substance use disorder (not currently using drugs illegally)
Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
Blind or low vision
Cancer (past or present)
Cardiovascular or heart disease
Celiac disease
Cerebral palsy
Deaf or serious difficulty hearing
Diabetes
Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
Epilepsy or other seizure disorder
Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
Intellectual or developmental disability
Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
Missing limbs or partially missing limbs
Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
Partial or complete paralysis (any cause)
Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
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Traumatic brain injury
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Science
48 days ago
Senior Scientist
Anduril Industries · Huntsville, Alabama, United States
Anduril Industries is a defense technology company with a mission to transform U.S. and allied military capabilities with advanced technology. By bringing the expertise, technology, and business model of the 21st century’s most innovative companies to the defense industry, Anduril is changing how military systems are designed, built and sold. Anduril’s family of systems is powered by Lattice OS, an AI-powered operating system that turns thousands of data streams into a realtime, 3D command and control center. As the world enters an era of strategic competition, Anduril is committed to bringing cutting-edge autonomy, AI, computer vision, sensor fusion, and networking technology to the military in months, not years.
ABOUT THE JOB
Anduril – Rocket Motor Systems is seeking a Lead Scientist to join our organization. The Rocket Motor Systems business line designs, develops, and manufactures next-generation solid rocket motors for defense and space applications. The ideal candidate has extensive experience with numerous types of energetic materials and demonstrated expertise in one area of solid composite propellant manufacture and formulation. This role requires considerable knowledge of energetic materials chemistry, significant experience in rocket motor manufacturing, and demonstrated effectiveness as the principal investigator on internal research and development efforts.
WHAT YOU'LL DO
Execute production rocket motor contracts as the program propellant chemist.
Act as the principal investigator on at least one internal research and development effort.
Provide technical guidance on explosives chemistry and manufacturing.
Maintain databases and analyze technical data to ensure specification and regulatory compliance.
Support implementation of innovative techniques and technologies.
REQUIRED QUALIFICATIONS
Ph.D. in Chemistry, Chemical Engineering, Aerospace Engineering, or a related field plus two years of experience; or a master’s degree plus four years of experience; or a bachelor’s degree plus six years of experience.
Minimum of two years of relevant experience within the aerospace/defense industry, preferably in solid rocket motor production.
Demonstrated expertise in some area of rocket motor manufacture, e.g., composite propellants, energetic materials, case/nozzle/insulation design, solid rocket motor manufacturing.
Demonstrated problem-solving skills and the ability to operate in a fast-paced, challenging environment.
Ability to obtain and hold a U.S. Secret Security Clearance..
PREFERRED QUALIFICATIONS
Ph.D. or M.S. in Chemistry with a concentration in energetic materials, polymer chemistry, or reactive materials.
Minimum of three years of relevant experience within the aerospace/defense industry, preferably in solid rocket motor production.
Demonstrated experience formulating propellants at laboratory or production size.
Active DOD Secret or Top-Secret security clearance.
At least one publication or presentation within the defense industry in a relevant journal or at a relevant conference.
US Salary Range
$128,000—$171,000 USD
The salary range for this role is an estimate based on a wide range of compensation factors, inclusive of base salary only. Actual salary offer may vary based on (but not limited to) work experience, education and/or training, critical skills, and/or business considerations. Highly competitive equity grants are included in the majority of full time offers; and are considered part of Anduril's total compensation package. Additionally, Anduril offers top-tier benefits for full-time employees, including:
Benefits
At Anduril, we invest in our people. Our comprehensive, competitive benefits package (available at little to no cost to employees) ensures you’re supported in health, recovery, and whatever comes next. For more information, Explore Our Benefits.
Protecting Yourself from Recruitment Scams
Anduril is committed to maintaining the integrity of our Talent acquisition process and the security of our candidates. We've observed a rise in sophisticated phishing and fraudulent schemes where individuals impersonate Anduril representatives, luring job seekers with false interviews or job offers. These scammers often attempt to extract payment or sensitive personal information.
To ensure your safety and help you navigate your job search with confidence, please keep the following critical points in mind:
No Financial Requests: Anduril will never solicit payment or demand personal financial details (such as banking information, credit card numbers, or social security numbers) at any stage of our hiring process. Our legitimate recruitment is entirely free for candidates.
Please always verify communications:
Direct from Anduril: If you receive an email from one of our recruiters, it will only come from an address.
Via Agency Partner: If contacted by a recruiting agency for an Anduril role, their email will clearly identify their agency. If you suspect any suspicious activity, please verify the agency's authenticity by reaching out to contact@anduril.com.
Exercise Caution with Unsolicited Outreach: If you receive any communication that appears suspicious, contains grammatical errors, or makes unusual requests, do not engage. Always confirm the sender's email domain is @anduril.com before providing any personal information or clicking on links.
What to Do If You Suspect Fraud: Should you encounter any questionable or fraudulent outreach claiming to be from Anduril, please report it immediately to contact@anduril.com. Your proactive caution is invaluable in protecting your personal information and upholding the security and trustworthiness of our recruitment efforts.
By submitting your application, you consent to Anduril Industries using a third-party service provider to conduct pre-employment risk, integrity, and due diligence screening and assessing potential risks as part of your application process. This third-party service provider provides risk-intelligence services that may include analysis of sanctions and watchlists, adverse media, public-record information, and other lawful open-source or commercial data sources. This third-party service provider does not act as a consumer reporting agency. Use of this provider helps to ensure compliance with applicable laws and protect technology, intellectual property, and organizational security.
Listed by Anduril Industries for a position based in the United States. Employers on this board attest they are hiring domestically.
Science
48 days ago
Senior Scientist
Anduril Industries · Huntsville, Alabama, United States
Anduril Industries is a defense technology company with a mission to transform U.S. and allied military capabilities with advanced technology. By bringing the expertise, technology, and business model of the 21st century’s most innovative companies to the defense industry, Anduril is changing how military systems are designed, built and sold. Anduril’s family of systems is powered by Lattice OS, an AI-powered operating system that turns thousands of data streams into a realtime, 3D command and control center. As the world enters an era of strategic competition, Anduril is committed to bringing cutting-edge autonomy, AI, computer vision, sensor fusion, and networking technology to the military in months, not years.
BOUT THE JOB
Anduril – Rocket Motor Systems is seeking a Lead Scientist to join our organization. The Rocket Motor Systems business line designs, develops, and manufactures next-generation solid rocket motors for defense and space applications. The ideal candidate has extensive experience with numerous types of energetic materials and demonstrated expertise in one area of solid composite propellant manufacture and formulation. This role requires considerable knowledge of energetic materials chemistry, significant experience in rocket motor manufacturing, and demonstrated effectiveness as the principal investigator on internal research and development efforts.
WHAT YOU'LL DO
Execute production rocket motor contracts as the program propellant chemist.
Act as the principal investigator on at least one internal research and development effort.
Provide technical guidance on explosives chemistry and manufacturing.
Maintain databases and analyze technical data to ensure specification and regulatory compliance.
Support implementation of innovative techniques and technologies.
REQUIRED QUALIFICATIONS
Ph.D. in Chemistry, Chemical Engineering, Aerospace Engineering, or a related field plus two years of experience; or a master’s degree plus four years of experience; or a bachelor’s degree plus six years of experience.
Minimum of two years of relevant experience within the aerospace/defense industry, preferably in solid rocket motor production.
Demonstrated expertise in some area of rocket motor manufacture, e.g., composite propellants, energetic materials, case/nozzle/insulation design, solid rocket motor manufacturing.
Demonstrated problem-solving skills and the ability to operate in a fast-paced, challenging environment.
Ability to obtain and hold a U.S. Secret Security Clearance..
PREFERRED QUALIFICATIONS
Ph.D. or M.S. in Chemistry with a concentration in energetic materials, polymer chemistry, or reactive materials.
Minimum of three years of relevant experience within the aerospace/defense industry, preferably in solid rocket motor production.
Demonstrated experience formulating propellants at laboratory or production size.
Active DOD Secret or Top-Secret security clearance.
At least one publication or presentation within the defense industry in a relevant journal or at a relevant conference.
US Salary Range
$128,000—$171,000 USD
The salary range for this role is an estimate based on a wide range of compensation factors, inclusive of base salary only. Actual salary offer may vary based on (but not limited to) work experience, education and/or training, critical skills, and/or business considerations. Highly competitive equity grants are included in the majority of full time offers; and are considered part of Anduril's total compensation package. Additionally, Anduril offers top-tier benefits for full-time employees, including:
Benefits
At Anduril, we invest in our people. Our comprehensive, competitive benefits package (available at little to no cost to employees) ensures you’re supported in health, recovery, and whatever comes next. For more information, Explore Our Benefits.
Protecting Yourself from Recruitment Scams
Anduril is committed to maintaining the integrity of our Talent acquisition process and the security of our candidates. We've observed a rise in sophisticated phishing and fraudulent schemes where individuals impersonate Anduril representatives, luring job seekers with false interviews or job offers. These scammers often attempt to extract payment or sensitive personal information.
To ensure your safety and help you navigate your job search with confidence, please keep the following critical points in mind:
No Financial Requests: Anduril will never solicit payment or demand personal financial details (such as banking information, credit card numbers, or social security numbers) at any stage of our hiring process. Our legitimate recruitment is entirely free for candidates.
Please always verify communications:
Direct from Anduril: If you receive an email from one of our recruiters, it will only come from an address.
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Listed by Anduril Industries for a position based in the United States. Employers on this board attest they are hiring domestically.
Staff Computational Biologist
Remote
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About this opportunity:
At Freenome, we are seeking a seasoned Staff Computational Biologist to help grow the Freenome Computational Science team. The ideal candidate is an expert in computational biology, genomics, and modeling, with a proven track record in industry settings. In this role, you will apply your background in computational biology and statistics to drive the creation of new applications and enhance algorithms for identifying molecular signatures of cancer. You will collaborate closely with machine learning scientists and computational biologists to iteratively advance computational models and assays, playing a key role in bringing products to the clinic. By joining us, you will have a significant impact on the continued growth of an organization dedicated to changing the entire landscape of cancer.
The role reports to the Manager and Staff Computational Biologist leading genomics modeling within Computational Science. This position can be onsite, hybrid, or remote (US only), based out of our campus in Brisbane, California.
What you’ll do:
Serve as a key thought-leader on the Computational Science team, leading the analysis and interpretation of cancer's molecular signatures and staying current with the field.
Guide and contribute to the development of models that characterize biological changes associated with cancer.
Execute rigorous computational analyses on data from best-in-class molecular assays, including whole genome sequencing, whole genome bisulfite sequencing, targeted sequencing, RNA sequencing, and protein quantitation.
Design novel statistical models for the evaluation, characterization, and modeling of these data types within the context of cancer biology and progression.
Identify research hypotheses and potential areas for model improvement; plan, scope, and execute associated research projects with a skilled team of computational biologists.
Solve complex analytical challenges inherent to the study of cell-free circulating nucleic acids and proteins.
Partner closely with molecular biologists to collaboratively refine wet lab experiments, and with development scientists to turn research models into products.
Support the professional development and career growth of talented, cross-functional computational biologists within your team.
Must haves:
PhD or equivalent experience in a relevant quantitative field (e.g., computational biology, cancer biology, statistics, bioinformatics).
At least 8 years of post-PhD experience applying computational techniques for biological discovery and product development, preferably in cancer or diagnostics within an industry setting.
Deep expertise in cancer and molecular biology, with a proven ability to leverage this knowledge for computational biology and diagnostics problems in cancer.
Extensive experience analyzing data and developing models for high-throughput, quantitative technologies in genomics, epigenomics, transcriptomics, proteomics, (e.g., Methyl-seq, ATAC-seq, RNA-seq, Hi-C, immunodetection assays).
Proficiency in computational and programming skills, including extensive experience with Python statistical packages (Numpy, Matplotlib, Pandas) and modeling packages (Scikit-learn, TensorFlow, PyTorch) or equivalents in languages like R or C/C++.
Nice to haves:
Experience training, evaluating, or applying biological sequence models—specifically sequence-to-function models that learn and predict functional biology directly from raw DNA, RNA, or protein sequences.
Experience developing or applying single-cell genomic or transcriptomic models to translate biological heterogeneity into generalizable regulatory or epigenomic signatures.
Experience modeling cell-free DNA (cfDNA) signals specifically for early disease detection and diagnostic applications.
Benefits and additional information:
The US target range of our base salary rate for new hires is $188,275 - $270,375. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.
Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Applicants have rights under Federal Employment Laws.
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ABOUT MERCOR
Mercor's mission is to organize human intelligence to power the AI economy. We're a leading AI data company, building the layer between human expertise and frontier models. Millions of domain experts on the platform are paid over $4 million per day to train frontier AI models. Mercor's APEX benchmark family measures AI's real-world impact on professional work. Mercor Enterprise brings this same infrastructure to Fortune 500 companies: helping companies capture how their best people actually work, translating that expertise directly back into agents.
Mercor is creating a new category of work where expertise powers AI advancement. Achieving this requires an ambitious, fast-paced and deeply committed team. You’ll work alongside researchers, operators, and AI companies at the forefront of shaping the systems that are redefining society. Mercor is a profitable Series C company valued at $10 billion. We work in-person five days a week in our San Francisco, NYC, or London offices.
ABOUT THE ROLE
In the Research Operations role at Mercor, you will work at the intersection of engineering and applied AI research. This role will own multi-million-dollar data programs end to end with responsibilities to:
- Reason about opportunities for frontier coding models, and translate that into the data that will make it stronger.
- Shape how data gets produced, including human-expert workflows, synthetic generation pipelines, and model-in-the-loop systems.
- Turn designs into scaled, high-quality data pipelines and own deliveries to customers.
- Build deep relationships with lab researchers and become the person they trust to tell them what data they actually need.
WHAT WE'RE LOOKING FOR
- Bachelor’s degree in Computer Science, a STEM field, or an equivalent technical discipline.
- At least two years of experience in software development or a forward deployed engineering role.
- A track record of running complex, high-stakes projects end to end, and genuine energy for large-scale execution and gritty process optimization under pressure.
- Strong analytical and communication skills; comfortable owning high-profile relationships with technical customers.
NICE TO HAVE
- Experience designing scalable data or automation pipelines
- Research fluency: connecting model/benchmark literature to what data would move a frontier model; having created a benchmark or published analysis of model behavior.
- Backgrounds that often fit: data scientists, software engineers, or forward deployed engineers who love operating, technical PMs, research engineers, or strong generalist operators with real technical range. Backgrounds from consulting, finance, or high-growth startups can work if paired with real technical fluency.
BENEFITS
- Bi-annual performance bonus structure
- Generous equity grant vested over 4 years
- Up to $15k Relocation bonus
- $10K proximity bonus (if you live within 0.5 miles of our office)
- $1.5K monthly stipend for meals
- Free Equinox membership
- $200 monthly laundry reimbursement
- $200 monthly personal wellness reimbursement
- Health, Dental, Vision insurance
Listed by Mercor for a position based in the United States. Employers on this board attest they are hiring domestically.
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Scientist II/Sr. Scientist I, Chemical Biology
Boston, MA
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Salary Band: $145,000-$185,000
Location: Boston, MA
Job Summary
Antares Therapeutics is seeking a motivated and detail-oriented Scientist II/ Sr Scientist I to join our Chemical Biology team. As a member of the team, you will be responsible for designing and executing proteomic screens to identify and validate novel therapeutic targets, elucidate mechanisms of inhibition, and enable biophysical small-molecule characterization through cycles of hit identification and SAR advancement. Achieving these objectives will involve the application of innovative chemoproteomic methodologies and the utilization of advanced HPLC and mass spectroscopy (MS) instrumentation. This position offers a unique opportunity to work in a collaborative, fast-paced environment at the intersection of chemistry and biology.
Key Responsibilities
Serve as the chemical biology functional lead on programs, reporting and presenting discovery evidence for multiple small-molecule programs
Design and execution of MS-based chemical biology experiments supporting target hit finding, compound profile optimization, and mechanism-of-action studies
Analyze experimental data, interpret results, and present findings at internal meetings. Maintain accurate and detailed laboratory records as well as up-to-date electronic notebooks
Design and execute quantitative proteomics experiments using data-independent acquisition (DIA) or targeted workflows
Contribute to the development of new proteomic workflows and the evaluation of emerging chemical biology strategies
Help maintain Orbitrap-based mass spectrometer and HPLC instrumentation
Professional Experience/Qualifications
PhD. in Chemical Biology, Analytical Chemistry, Biochemistry, Proteomics, or a related discipline with 2–6 years of relevant industry and/or postdoctoral experience
Proficiency in operating and maintaining mass spectrometry and liquid chromatography instrumentation is required
Previous experience with MS-based proteomic methods to study protein/peptide modification, protein turnover, and/or targets using enrichment methods is required
Experience in small molecule drug mechanisms of action (e.g., covalent ligands, molecular glues, PROTACs, etc.) is desirable
Knowledge/experience with activity-based protein profiling (ABPP) is desirable
Familiarity with Proteome Discoverer, Skyline, DIA-NN, Spectronaut, MaxQuant, or related proteomics software is desirable
Programming experience and data analysis (g., Python or R) for statistical analysis, visualization, and interpretation of large biological datasets is desirable
Ability to perform routine laboratory tasks requiring manual dexterity, including pipetting, sample preparation, and operation of analytical instrumentation
The anticipated annual salary range for this position is $145,000-$185,000 annually. The actual salary offered will be based on a number of factors, including but not limited to the qualifications of the applicant, years of relevant experience, level of education attained, certifications or other professional licenses held, and if applicable, the location in which the applicant lives and/or from which they will be performing the job.
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Provide a specific example in your previous proteomics research experience where the detection/identification of a peptide/protein target(s) proved to be challenging. Explain how you identified the issue, what sample preparation and LC and/or MS approaches were taken to address the problem, how findings were used to enable reproducible LC-MS data collection, and what impact this made on the research.*
Antares research programs focus on covalent drug discovery. Describe specific research experiences that you have with detecting and quantifying covalent protein modification. What chemical biology and/or proteomics approaches have you employed to identify, characterize, and evaluate protein modification on cell biological behavior in these cases? What problems have you had to solve? How did your findings impact the understanding of the target’s function and regulation in normal biology or a disease state in the cases that you describe?*
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A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.
A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.
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Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.
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