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Chief Operating Officer Loyal · Remote - US $315k–425k 103 days ago Remote Business Development

Senior Director, Clinical Development Loyal · Remote - US $230k–270k 125 days ago Remote Biotech/Pharma

Director, Regulatory Affairs - Clinical Loyal · Remote - US $155k–205k 140 days ago Remote Biotech/Pharma

Business Development

103 days ago

Chief Operating Officer

Loyal · Remote - US

Pay

$315k–425k

Setting

Remote

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Back to jobs Chief Operating Officer Remote - US Apply About Loyal Loyal is a clinical-stage veterinary medicine company developing longevity drugs for dogs. Our mission is to help dogs live longer, healthier lives. We're pioneering a new category of veterinary prescription drugs that proactively and preventatively target the underlying drivers of aging, delaying the onset of disease and preserving quality of life as dogs age. We've already made significant progress in our mission to develop the first FDA-approved drugs to extend canine lifespan: as of early 2026 we've completed two of three major FDA review sections for our lead program, LOY-002, and are targeting submission of the third and final section later this year. Loyal is a well-funded startup with teams of scientists, veterinarians, engineers, operators, and creatives. You'll help us continue on our path of earning FDA approval for the first lifespan extension medicine for any species, and change what's possible for the dogs we love. About the role Loyal is hiring a Chief Operating Officer. This is a hands-on leadership role at a company that has closed a $100M Series C, is advancing three+ pipeline programs, and is targeting commercial launch of its first product LOY-002 in 2027. You will own Finance, People, Engineering, Program Leadership, Commercial, Customer Service, and the internal operating system that runs the company. The right person has stood up operating systems in startups before, has the confidence and conviction to push back on a founder/CEO, and can credibly hold a commercial projections debate, a product review, and a supply chain negotiation session in the same week. Your daily work will include Owning the operational execution of Loyal's first commercial launch in 2027 - partnering with organizations including Commercial, CMC/Supply Chain (under the CTOO), Veterinary Medicine, and Creative to ensure a launch that performs commercially and earns a brand customers love. Leading Finance, People, Program Leadership, Commercial, Customer Service, and both Commercial and Internal/Platform Engineering. You will directly manage the leaders running each function, and build/scale the organizations where the organization is not yet built out. Scaling the company from ~70 to ~150 people with AI-leveraged efficiency — headcount growth gated to commercial milestones, not arbitrary expansion. Deploying AI tooling across ops, finance, recruiting, and customer service so leverage scales with the team. Iterating and owning the operating cadence the company runs on — goals system, weekly and monthly business reviews, and the board prep cadence. Owning the seam between commercial demand and technical supply — running the S&OP cadence with the CTOO so the CEO is not the integrator on day-to-day operational decisions. Leading product distribution platform buildout for a very complicated and regulated flow (prescription drug distribution), in collaboration with our engineering and commercial leadership. Building a customer service organization that scales with launch and that creates a pharma brand customers genuinely love. Acting as the company-wide problem solver — proactively identifying and resolving operational issues across functions before they become roadblocks. Freeing the CEO to focus ~80% of her time on external work (board, investors, partnerships, science narrative, brand) by the time of launch. About you 10+ years of operating experience at high-growth startups where you've directly built and scaled the operations function through inflection points, including at least one company in the 50–300 headcount range. Both startup AND scale experience. You've built v1 systems from scratch and iterated them to v3 — not pure startup, not pure big-co. Technical credibility. You've led engineering, data, or other technical disciplines that you weren't personally an expert in. You can explain complex ideas simply and hold credibility in technical reviews. Bio background is not required but you should be excited to build basic bio and drug development fluency. Commercially literate. You will manage our existing Commercial executive and help build the team around them. You don't need a career commercial background, but you do need to credibly challenge and coach commercial leadership. You should have good taste or be self-aware that you do not - and be able to hire around that. First-principles thinker. You drill quickly to the load-bearing question in disciplines you don't fully know yet. Low ego, high confidence, high integrity. You suppress your ego to execute the founder's vision, and you have the bravery to push back when you think she's wrong. AI-leveraged operator. You use AI tools in your own workflow today and have a point of view on deploying them across the org for compounding leverage. Concise, high-information-density communicator. You write well and default to async written briefs over meetings. Strong manager and developer of people. You set clear expectations, hold people accountable, and your direct reports get measurably better at their jobs within months. You do not shy away from giving direct feedback quickly and are impatient with mediocre performance in yourself and your team. You are not corporate. High agency, exceptional follow-through. You track many disparate things at once and nothing falls through. You build systems and processes that outlast you. You work hard. Mission-aligned. Whether for dogs, longevity, building an aging pharma, or building a consumer pharma brand people love — this matters to you for reasons that pre-date this job posting. Preferred attributes Experience supporting a first commercial launch at a VC-backed biotech, medical device, or other regulated atoms business. Background in or adjacent to veterinary or animal health, consumer health pharma, or a DTC business with a regulated product. Track record of building a function 0→1 and intentionally handing it off to a specialist leader as the org matured. Cat lovers accepted. Why you may not be a fit You have no experience operating without enterprise infrastructure and have never built a function from scratch with no team and no playbook. You lean towards heavy processes and have a playbook that you have utilized at multiple companies. You have not worked closely with non-engineering technical staff (scientists, doctors, veterinarians, etc). You want a well-defined role - this role is broad, messy, and high-ownership by design. You don't use AI in your own work today and don't have a strong view on how to deploy it. You are not comfortable leading and operating in a milestone-based, pre-revenue business for 12-24 months You are not comfortable operating in a remote-first environment or traveling regularly to visit our distributed team. Salary Range: $315,000 - $425,000 Loyal benefits Full-coverage health insurance — medical, dental, and vision — for you and your dependents $1,000 home office equipment stipend $1,200/year learning budget for books, courses, etc. $250/month wellness budget for gym, cleaners, spa, food, etc. All 3-day weekends are turned into 4-day weekends Unlimited vacation and paid holidays Paw-ternity leave — adopt a dog and get a day off with your new family member Competitive salary Company equity options grant for new hires Loyal is founded and led by a first-gen female CEO and is proud to be an equal opportunity employer. We do not discriminate against applicants based on gender, race or color, ethnicity or national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or any other applicable characteristics protected by law. Our values Moonshots, derisked methodically Bringing the first longevity drug to market is an extremely difficult technical and social pursuit. To achieve this we must take bigger bets than the field has historically made, paired with the technical rigor to de-risk them step by step. We plan on both short and extremely long timescales, and we have the conviction to see our vision through to success or failure. Opportunity is at the intersection We lean into combining disciplines, expertise, and perspectives not normally adjacent. We design our organization to facilitate cross-pollination and cross-collaboration. We reject silos. Expertise without ego Titles do not determine who has a voice. We push back on each other, ask questions instead of issuing orders, and try to prove ourselves wrong. We are emotionally attached to the outcome, not our personal hypotheses, and welcome being challenged instead of treating it as a threat. High agency, high humility Most of what we're doing has never been done before, so we can't rely on established precedents to guide our way. We move forward to generate clarity, build strategies resilient to the fact that we don't know what we don't know, and design small experiments where we can fail safely, without jeopardizing the bigger mission. Lead with transparency and context We proactively and consistently share the why behind our strategy — not just the what — because we believe sharing context enables great people to make great decisions. Empathy and respect for all life Our patients are not just numbers. We deeply respect the value of every life, large and small and take our ethical responsibility to the families we treat extremely seriously. Get new jobs like this in your inbox We'll email you when Loyal posts a job like this one. Create alert Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country* Phone* Location (City)* Locate me Resume/CV* Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Do you now or in the future require sponsorship for employment?* Select... LinkedIn Profile Website Submit application Powered by

Listed by Loyal for a position based in the United States. Employers on this board attest they are hiring domestically.

Biotech/Pharma

140 days ago

Director, Regulatory Affairs - Clinical

Loyal · Remote - US

Pay

$155k–205k

Setting

Remote

Apply Sign in to favorite Permalink

Back to jobs Director, Regulatory Affairs - Clinical Remote - US Apply About Loyal Loyal is a clinical-stage veterinary medicine company developing longevity drugs for dogs. Our mission is to help dogs live longer, healthier lives. We're pioneering a new category of veterinary prescription drugs that proactively and preventatively target the underlying drivers of aging, delaying the onset of disease and preserving quality of life as dogs age. We've already made significant progress toward our first regulatory approvals, with additional submissions targeted in the near future. Loyal is a well-funded startup with teams of scientists, veterinarians, engineers, operators, and creatives. You'll help us continue on our path of earning FDA approval for the first lifespan extension medicine for any species, and change what's possible for the dogs we love. About the role We’re seeking an experienced Director Regulatory Affairs, Clinical to serve as Loyal’s subject matter expert on FDA Center for Veterinary Medicine (CVM) regulatory strategy and clinical trial operations. This is a high-impact, hands-on role for someone who thrives on owning complex regulatory programs end-to-end — from INAD strategy through pivotal submission — and who brings deep expertise in FDA CVM clinical development. You will be the primary interface between Loyal and FDA CVM for clinical regulatory matters, owning our regulatory submissions, and helping shape the strategies that bring our longevity drugs to market. You will also manage 1–2 direct reports as the team grows. Your work will directly shape the regulatory path to bring novel longevity therapeutics through FDA CVM approval for the first time in any species, setting regulatory precedent for an entirely new category of medications. This role is for someone who has at least 10+ years of regulatory affairs experience. The ideal candidate should be a strategic thinker that is comfortable owning complex, first-of-kind regulatory programs with limited precedent, possess deep working knowledge of FDA CVM clinical development pathways and submission requirements and thrive in an environment operating with a great deal of autonomy in setting direction, making judgement calls, and driving programs and regulatory pathways forward in an agile organization. You will be reporting to our VP of Regulatory Affairs . Your daily work will include Authoring and reviewing regulatory submissions, including INAD filings, study reports, clinical trial evaluability meetings, and agency correspondence Leading preparation for FDA CVM meetings, including briefing documents, meeting requests, posing questions, and follow-up MOCs Partnering with clinical teams to provide real-time regulatory guidance on active studies, including SAE submissions, BIMO preparedness, and NCIE reports Reviewing and preparing study protocols, ICFs, and amendments to ensure the highest quality submissions for pivotal protocol concurrence Monitoring and interpreting CVM guidance, policy updates, and precedent to inform Loyal's regulatory strategy across our pipeline Anticipating and resolving regulatory risks across functions (including R&D, CMC, and commercial) throughout the portfolio before they become problems Managing and mentoring 1–2 direct reports, providing feedback, priorities, and development support Collaborating cross-functionally with R&D, clinical development, clinical operations, data management, and legal teams on submissions and strategy Oversee the maintenance and organization of all regulatory records and interactions related to Loyal’s drug programs Serving as the internal subject matter expert for any question touching FDA CVM clinical requirements — from study design to labeling to adverse event reporting Reviewing and advising on external facing pre-approval communications and activities to ensure compliance with FDA CVM regulations Reviewing and providing guidance on labeling materials for submission to ensure compliance with FDA CVM regulations About you Bachelor’s degree in relevant field (biology, vet med, regulatory affairs or related); relevant experience > specific degree 10+ years of regulatory affairs experience with with 3+ years in animal health, direct experience with owning FDA/CVM relationships. Hands on ownership experience with INADs, regulatory submissions, and FDA CVM in-person meetings Background across multiple drug types ideal (small molecules, biologics, injectables, etc.) You are data-driven and an analytical thinker; your regulatory experience is grounded in evidence and you communicate with excellence Strong and experienced writer that takes pride in clarity, accuracy and persuasive story telling about biological pathways or drug mechanisms and clinical impacts Extensive knowledge of FDA CVM regulatory pathways, policies, and limitations and where there are areas to innovate within those bounds Excellent judgement where FDA CVM is concerned and comfortable being the single source of strategic conviction using that judgement Collaborative with cross-functional teams and not afraid to be in the weeds while also being the subject matter expert Ability to operate as a high level individual contributor while also serving as a mentor to junior team members in order to upskill the department. Energized by a fast-paced startup environment Salary Range: $155,000 - $205,000 Loyal benefits Full-coverage health insurance — medical, dental and vision — for you and your dependents $1,000 home office equipment stipend $1,200/year learning budget for books, courses, etc. $250/month wellness budget for gym, cleaners, spa, food, etc. All 3-day weekends are turned into 4-day weekends 🎉 Unlimited vacation and paid holidays Paw-ternity leave — adopt a dog and get a day off with your new family member 🐶 Competitive salary Company equity options grant for new hires Loyal is founded and led by a first-gen female CEO and is proud to be an equal opportunity employer. We do not discriminate against applicants based on gender, race or color, ethnicity or national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, or any other applicable characteristics protected by law. Our values Moonshots, derisked methodically Bringing the first longevity drug to market is an extremely difficult technical and social pursuit. To achieve this we must take bigger bets than the field has historically made, paired with the technical rigor to de-risk them step by step. We plan on both short and extremely long timescales, and we have the conviction to see our vision through to success or failure. Opportunity is at the intersection We lean into combining disciplines, expertise, and perspectives not normally adjacent. We design our organization to facilitate cross-pollination and cross-collaboration. We reject silos. Expertise without ego Titles do not determine who has a voice. We push back on each other, ask questions instead of issuing orders, and try to prove ourselves wrong. We are emotionally attached to the outcome, not our personal hypotheses, and welcome being challenged instead of treating it as a threat. High agency, high humility Most of what we're doing has never been done before, so we can't rely on established precedents to guide our way. We move forward to generate clarity, build strategies resilient to the fact that we don't know what we don't know, and design small experiments where we can fail safely, without jeopardizing the bigger mission. Lead with transparency and context We proactively and consistently share the why behind our strategy - not just the what - because we believe sharing context enables great people to make great decisions. Empathy and respect for all life Our patients are not just numbers. We deeply respect the value of every life, large and small and take our ethical responsibility to the families we treat extremely seriously. Apply for this job * indicates a required field Autofill my application First Name* Last Name* Email* Phone Country* Phone* Location (City)* Locate me Resume/CV* Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Cover Letter Attach Attach Enter manually Enter manually Accepted file types: pdf, doc, docx, txt, rtf Do you now or in the future require sponsorship for employment?* Select... LinkedIn Profile Website Submit application Powered by

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